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Use of nmn for preventing and/or treating pain and corresponding composition

One-NMN, the technology of use, applied in the direction of drug combination, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as obstructed respiratory muscles, adverse reactions, and allergies to conventional analgesics

Pending Publication Date: 2022-04-29
NUVAMID SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for morphine and opiate derivatives, which cause serious adverse effects, especially high risk of physical and psychological dependence
Also, overdose of morphine can block breathing muscles and can be fatal
[0018] Finally, some patients may develop hypersensitivity to conventional analgesics

Method used

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  • Use of nmn for preventing and/or treating pain and corresponding composition
  • Use of nmn for preventing and/or treating pain and corresponding composition
  • Use of nmn for preventing and/or treating pain and corresponding composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0407] The effectiveness of using NMNs according to the invention was evaluated in a rat nociceptive pain model. More precisely, the model used is the visceral pain model. Administration of cyclophosphamide (CYP) was used as a method to simulate cystitis in rats.

[0408] The positive control was ibuprofen, a non-steroidal anti-inflammatory drug commonly used to relieve nociceptive pain. Negative controls were NMN and ibuprofen vehicle, ie, distilled water.

[0409] In this study, 7-week-old female Sprague-Dawley rats were divided into three groups, each consisting of 6 rats:

[0410] - control group receiving 5 ml of distilled water (vehicle);

[0411] - the group treated with 500 mg / kg of NMN; and

[0412] - Group treated with 300 mg / kg ibuprofen.

[0413] NMN is in the zwitterionic form.

[0414] After 24 hours of acclimatization, the pain tolerance threshold of each animal was measured using von Frey fibrils before the start of the study. Measurements were taken pri...

Embodiment 2

[0436] Synthesis of compounds of the present invention

[0437] Materials and methods

[0438] All reagents were obtained from commercial suppliers and used without further purification. Thin layer chromatography was performed on TLC silica gel 60F254 plastic plates (0.2 mm layer thickness) from Merck. Column chromatography purification was performed on silica gel 60 (70-230 mesh ASTM, Merck). Melting points were determined either on a digital device (electrothermal IA 8103), uncorrected, or on a Kofler heating stage WME type (Wagner & Munz). 1 H. 19 F and 13 C Nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy confirmed the structures of all compounds. Infrared spectra were recorded on a Perkin Elmer Spectrum 100FT-IR spectrometer; and NMR spectra were recorded using CDCl 3 、CD 3 CN, D 2 O or DMSO-d 6 as solvent, recorded at 300 or 400 MHz on a BRUKER AC 300 or 400 spectrometer 1 H spectrum, recorded at 75 or 100MHz 13 C Spectrum, recorded at 282 or 37...

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PUM

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Abstract

The present invention relates to nicotinamide mononucleotides, pharmaceutically acceptable precursors thereof, pharmaceutically acceptable derivatives thereof or pharmaceutically acceptable salts thereof for use in the prevention and / or treatment of pain, in particular nociceptive pain; the invention also relates to a composition comprising the same.

Description

[0001] field of invention [0002] The present invention relates to the use of nicotinamide mononucleotide (NMN), its pharmaceutically acceptable derivative or its pharmaceutically acceptable salt for treating and / or preventing pain, especially nociceptive pain. The present invention also relates to a composition comprising NMN, a pharmaceutically acceptable derivative thereof or a pharmaceutically acceptable salt thereof, for the treatment and / or prevention of pain, especially nociceptive pain. Background technique [0003] Pain can be both a symptom and a disease. The International Association for the Study of Pain (IASP) defines pain as "an unpleasant sensory and emotional experience associated with or similar to actual or potential tissue damage" (see definition at the following link in the updated version on December 14, 2017: https: / / www.iasp-pain.org / Education / Content.aspx? ItemNumber=1698&navItemNumber=576#Pai ). Pain is information processed by the nervous syste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K45/06A61P29/00
CPCA61K31/706A61K45/06A61P29/00A61K31/7084A61P29/02
Inventor G·伯蒙德L·加龙
Owner NUVAMID SA