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Micro-fluidic chip of multi-fetal placenta vascular anastomosis model, system and use method

A microfluidic chip and simulation system technology, applied in the field of microfluidics, can solve problems such as application limitation of single-fetus maternal-fetal barrier and other problems

Active Publication Date: 2022-05-06
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, microfluidic organ chips have been developed to study the immune response of the maternal-fetal interface, placental uptake and transportation, drug transport, etc., but its application is limited to the single-fetal maternal-fetal barrier. mechanism still to be explored

Method used

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  • Micro-fluidic chip of multi-fetal placenta vascular anastomosis model, system and use method
  • Micro-fluidic chip of multi-fetal placenta vascular anastomosis model, system and use method
  • Micro-fluidic chip of multi-fetal placenta vascular anastomosis model, system and use method

Examples

Experimental program
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Embodiment 1

[0054] This embodiment discloses a microfluidic chip of a multi-fetal placental vascular anastomosis model, such as figure 1 As shown, the chip body 1 is included, the chip body 1 is provided with a maternal fluid channel 103 and two or more fetal fluid channels 104, a porous membrane 2 is arranged between the maternal fluid channel 103 and the fetal fluid channel 104, and the fetal fluid channel There are connecting channels between the channels 104 that can be connected or disconnected.

[0055] In this embodiment, when there are two fetal fluid channels 104, it is used to simulate the twin placental vascular anastomosis model, when there are three fetal fluid channels 104, it is used to simulate the placental vascular anastomosis model of triplets, and so on to simulate multiple Fetoplacental vascular anastomosis model.

[0056] In this embodiment, the porous membrane 2 is preferably but not limited to porous polycarbonate membrane, polyester membrane, polytetrachlorethyle...

Embodiment 2

[0068] This embodiment provides a microfluidic chip of a multi-fetal placental vascular anastomosis model, such as Image 6 and Figure 7 As shown, the microfluidic chip includes a chip body 1, and the chip body 1 is provided with a maternal fluid channel 103 and two or more fetal fluid channels 104, and a porous membrane is arranged between the maternal fluid channel 103 and the fetal fluid channel 104. 2. A connection channel that can be connected or disconnected is provided between the fetal fluid channels 104 . The connecting channels include a first connecting channel 105 that enables two-way or multi-directional communication between the fetal fluid channels 104 , and a second connecting channel 106 that is connected to the fetal fluid channel 104 and allows only one-way flow of fluid.

[0069] The difference between this embodiment and Embodiment 1 is: First, this embodiment arranges all or part of the fluid channel 104 and the matrix fluid channel 103 on the same side...

Embodiment 3

[0079] Embodiment 3 This embodiment discloses a multiple-fetal placental vascular anastomosis simulation system, including the microfluidic chip provided in Embodiment 1 or Embodiment 2 and at least 3 fluid pumps, using multiple fluid pumps to provide fetal fluid channels 104 and The parent fluid channel 103 pumps fluid.

[0080] In this embodiment, preferably, fluid is pumped into the input connection port of the second connection channel 106 through a separately provided fluid pump. The fluid pump is not the fluid pump of the fetal fluid channel 104 and the maternal fluid channel 103, but is a separate fluid pump.

[0081] In this embodiment, the fluid pumps are respectively connected to the input connection ports of the fetal fluid channel 104 , the maternal fluid channel 103 , and the second connection channel 106 to pump fluid into the channels. The fluid pump is preferably but not limited to a two-way continuous syringe pump model WH-BCSP-22. The output port of the pump...

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Abstract

The invention discloses a micro-fluidic chip of a multi-fetal placenta vascular anastomosis model, a system and a use method. The micro-fluidic chip comprises a chip body, a maternal fluid channel and two or more fetal fluid channels are arranged on the chip body, a porous membrane is arranged between the maternal fluid channel and the fetal fluid channels, and connecting channels which can be connected or disconnected are arranged between the fetal fluid channels. The placenta structure of multiple births such as twins or triplets is accurately and completely miniaturized and reconstructed, the placenta microstructures of two different chorionic twins can be simulated, and a replacement model can be provided for the research on the current twins / multiple birth maternal fetal barrier and the research on the potential pathophysiological mechanism of the special complications of the twins; physiological flow conditions can be simulated so as to realize blood convection motion of two fetuses of twins and a maternal body; flow conditions can be changed to simulate abnormal blood flow environments of villus gaps and fetal capillaries and changes before and after therapeutic measures are administered.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic chip, a system and a use method of a multiple-fetal placenta vascular anastomosis model. Background technique [0002] Twin pregnancy has always been the focus of perinatal medicine and fetal medicine research. The natural pregnancy process and outcomes are diverse, especially monochorionic diamniotic twins. Because the two fetuses share a placenta, there is a 1 There are more than one vascular anastomosis in the superficial part of the placenta, and there are often arterial-arterial and venous-venous anastomoses with two-way blood flow in the superficial placenta, and vascular anastomoses in the deep placenta often show unidirectional blood flow. When there is no compensatory vascular anastomosis with superficial two-way blood flow It will lead to hemodynamic imbalance, so there may be more and more serious complications, accompanied by an increase in perina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/06C12M3/00B01L3/00
CPCC12M23/16C12M23/58C12M29/04C12M35/08B01L3/5027
Inventor 韩顶立冉瑞刘晓玉胡丽娜董晓静于廷和
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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