Rotary evaporation device for preparing lipidosome

Abstract

The invention provides a rotary evaporation device for preparing lipidosome. The rotary evaporation device is used for solving the problem that a film formed by an existing rotary evaporation device is poor in uniformity. Comprising an evaporation bottle for accommodating a to-be-evaporated substance; the evaporating pipe can be hermetically connected with the opening of the evaporating bottle; the condenser is connected with the evaporation bottle through an evaporation pipe and is used for condensing evaporated substances; the recovery bottle is connected with the condenser and is used for recovering substances condensed by the condenser; the lifting supporting column plays a bearing role and can adjust the height; the cantilever is mounted on the lifting supporting column, ascends and descends along with the lifting supporting column and is used for clamping the evaporation pipe; the first driver is mounted on the cantilever and drives the evaporation pipe and the evaporation bottle to rotate; the second driver is mounted on the lifting supporting column and drives the cantilever to rotate in a reciprocating manner, so that the evaporating flask swings by taking the cantilever as a circle center; and the heating kettle is used for heating the evaporation bottle. When the device runs, a thin film formed on the inner wall of the evaporation flask is wide in dispersion area and good in uniformity, and the device is suitable for preparing lipidosome through thin film dispersion.

Description

technical field [0001] The invention relates to the technical field of liposome preparation, in particular to a rotary evaporation device for preparing liposome. Background technique [0002] The preparation methods of liposomes mainly include injection method, film dispersion method, reverse evaporation method, ultrasonic dispersion method, freeze-drying method and the like. Among them, the film dispersion method is the most basic and widely used liposome preparation method. This method is to dissolve lipids such as phospholipids and cholesterol and fat-soluble substances to be encapsulated in an organic solvent, and then place the solution in In the round-bottomed flask, evaporate to dryness under reduced pressure, so that the phospholipids form a thin film on the inner wall of the flask, then add a certain amount of buffer solution, and the lipid film hydrates and falls off when fully shaken to obtain liposomes. [0003] The structure and function of the existing rotary ...

AI Technical Summary

Problems solved by technology

However, the uniformity of the film formed during the rotary evaporation of the existing rotary evaporator is relatively poor, and the poor uniformity of the film will affect the encapsulation effect of subsequent liposomes on substances, and there are problems such as low encapsulation efficiency.

In addition, the installation, connection, and disassembly of the existing rotary evaporator are cumbersome, prone to problems such as unstable installation and leakage, inconvenient use, and potential safety hazards

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