Closed hole type magnetic particle imaging device, system and method without field line scanning

Abstract

The invention belongs to the technical field of magnetic particle imaging, particularly relates to a closed hole type field-line-free scanning magnetic particle imaging device, system and method, and aims to solve the problems of complex structure, low space utilization rate, high power consumption and the like of the existing closed hole type three-dimensional field-line-free electric scanning MPI equipment. The device comprises a gradient module, a scanning module and an induction module, the gradient module is used for constructing and rotating a field-line-free gradient magnetic field, so that magnetic nanoparticles far away from field lines are saturated; the scanning module is used for constructing a uniform magnetic field to control the translational motion of the field-line-free gradient magnetic field along the radial direction or the axial direction of the imaging hole; the sensing module is used for collecting nonlinear response signals of the magnetic particles; three-dimensional field-line-free electric scanning magnetic particle imaging is achieved, the time resolution, the space resolution and the sensitivity of imaging are high, the imaging is not limited by tissue depth, and meanwhile the imaging device has the advantages of being simple in structure, high in space utilization rate, low in power consumption and the like.

Description

technical field [0001] The invention belongs to the technical field of magnetic particle imaging, and in particular relates to a closed-hole type fieldless line scanning magnetic particle imaging device, system and method. Background technique [0002] Magnetic Particle Imaging (MPI, Magnetic Particle Imaging) is based on the nonlinear response of Superparamagnetic Iron Oxide Nanoparticles (SPIO, Superparamagnetic Iron Oxide Nanoparticles) in alternating gradient magnetic field to obtain highly sensitive and quantitative acquisition of the concentration distribution of magnetic nanoparticles in vivo . Most of the current MPI systems construct a field free region (FFR), that is, a field free point (FFP) or a field free line (FFL), and receive magnetic fields in the FFR region through a highly sensitive coil. The magnetization response signal of the nanoparticles, and the image reconstruction is performed by spatially encoding the FFR scanning trajectories. Compared with fie...

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Problems solved by technology

[0004] In order to solve the above-mentioned problems in the prior art, that is, in order to solve the problems of the existing closed-cell three-dimensional field-line-free electronic scanning MPI equipment with complex structure, low space utilization, and high power consumption, the present invention provides a closed-cell Field-line-free scanning magnetic particle imaging device, system and method

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