Cell manipulation panel, cell separation device, and method for performing cell manipulation
A technology for operating panels and cells is applied in the fields of cell operating panels, cell separation devices and performing cell operations, and can solve the problems of reducing dielectrophoretic force, maintaining optical resolution, and consuming optical induction dielectrophoretic force, etc.
Pending Publication Date: 2022-06-03
AU OPTRONICS CORP
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Problems solved by technology
[0005] However, conventional optical-sensing DEP cell manipulation devices require a light source to generate an electric field, thus generating an optical-sensing DEP force that consumes more power
In addition, the light source requires a small field-of-view (FOV) to maintain the optical resolution of conventional optically-sensing DEP cell manipulation devices because the blurred light beam may lead to a significant decrease in DEP force.
Furthermore, traditional cell manipulation devices cannot realize cell manipulation on a large area
Method used
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[0119] The contents of the present case will now be described more fully with reference to the accompanying drawings, in which exemplary embodiments of the present case are shown. However, the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of this disclosure to those skilled in the art. Reference numerals refer to similar elements.
[0120] Terms used in this case generally have their ordinary meanings in the art, in the context of this case, and in the specific context in which the terms are used. Certain terms used to describe the case are discussed below or in the specification to provide practitioners with additional guidance regarding the description of the case. For convenience, certain terms may be emphasized, such as using italics and / or quotation marks. Th...
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A cell manipulation panel includes a pixel array defining a plurality of pixels, an insulating layer forming a plurality of through-holes, and a cell gap equipped with a fluid medium having cells therein. Each pixel has a thin film transistor and corresponds to a respective via. The thin film transistor comprises a gate electrode, a first electrode and a second electrode, and the second electrode is partially exposed to the fluid medium through a corresponding through hole. For each pixel, in an operating mode, when the gate electrode is provided with a turn-off signal and the first electrode is not grounded, the thin film transistor is turned off, thereby allowing one cell in the fluid medium to be captured by dielectrophoretic force in the respective through-hole. When the gate electrode is provided with a turn-on signal and the first electrode is grounded, the thin film transistor is turned on, and the second electrode is grounded to release the captured cells to the fluid medium.
Description
technical field [0001] This case relates generally to cell separation and manipulation technology, and more particularly to a thin film transistor-based cell separation device and its cell manipulation panel. Background technique [0002] The background description provided herein is intended to provide a general context for the present case. The work of the presently named inventor, within the scope described in this background section, and the aspect of the description that may not qualify as prior art at the time of filing the application, is neither expressly nor implied as prior art objection to this case. [0003] To better understand how cells function and change, researchers need to study individual cells to develop better drug formulations to prevent infectious diseases. Cell isolation and manipulation are essential for further analysis and have value for diagnostic, biotechnological, and biomedical applications in precision medicine. [0004] Currently, there are...
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IPC IPC(8): C12M1/42C12M1/36C12M1/00C12N13/00G06T7/00G06T7/62
CPCC12M35/02C12M41/00C12N13/00G06T7/0004G06T7/62G06T2207/10004G06T2207/30148G01N27/414C12M47/04G06V20/693C12M41/48G01N27/4145
Inventor 林东村郭志彻毛媛
Owner AU OPTRONICS CORP