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Lactobacillus rhamnosus strain wka55 and its use and product in the preparation of products for preventing and treating alcoholic liver damage

A technology of Lactobacillus rhamnosus, alcoholic liver injury, applied in the field of microorganisms, can solve problems such as ingredients that cannot be clearly defined

Active Publication Date: 2022-08-09
JIANGSU WECARE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the published documents or patents, for example, CN111004752B provides a strain of ethanol-resistant Lactobacillus plantarum and its application in fermented food, which is mainly used in the production of wine and vinegar brewing to improve the taste of products and increase the flavor of wine; CN111249371A What is provided is a liver-rescue and liver-protecting composition, which is a combination product, and the ingredients that really have an effective effect have not been clarified

Method used

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  • Lactobacillus rhamnosus strain wka55 and its use and product in the preparation of products for preventing and treating alcoholic liver damage
  • Lactobacillus rhamnosus strain wka55 and its use and product in the preparation of products for preventing and treating alcoholic liver damage
  • Lactobacillus rhamnosus strain wka55 and its use and product in the preparation of products for preventing and treating alcoholic liver damage

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0063] MRS medium used in Experimental Example 1: peptone 10 g, beef extract 10 g, yeast extract 5 g, glucose 20 g, K 2 HPO 4 2 g, Sodium Citrate 2 g, Mg SO 4 ·7H 2 O 0.2 g, sodium acetate 5.0 g, MnSO 4 ·4H 2 O 0.2 g, Tween 801 mL, 1 000 mL distilled water. Sterilize at 121°C for 20 min.

[0064] The mice used in Experimental Examples 4-8 were purchased from Hunan Slike Jingda Laboratory Animal Co., Ltd.

[0065] Unless otherwise specified, all kinds of reagent consumables used in the embodiments and experimental examples of the present invention are commercially available, and the relevant experimental steps are common operations in the art, and have technical meanings that can be routinely understood by those skilled in the art.

Embodiment 1

[0066] Embodiment 1, Lactobacillus rhamnosus WKA55 of the present invention ( Lacticaseibacillus rhamnosus )

[0067] The examples in this group provide a strain of Lactobacillus rhamnosus WKA55 ( Lacticaseibacillus rhamnosus ), is characterized in that, its deposit number is CCTCC NO: M 2022191.

[0068] Anyone who cultivates, propagates, ferments, produces, prepares, or uses the Lactobacillus rhamnosus WKA55 with the deposit number CCTCC NO: M 2022191 to prevent and / or treat alcoholic liver injury or use the deposit number CCTCC NO: M 2022191 The actions of Lactobacillus rhamnosus WKA55 for preventing and / or treating alcoholic liver injury by health care products / drugs / foods all fall within the protection scope of the present invention.

[0069] In a specific embodiment, the Lactobacillus rhamnosus WKA55 ( Lacticaseibacillus rhamnosus ) The nucleotide sequence of 16S rDNA is shown in SEQ ID NO.1.

[0070] In a specific embodiment, the acid resistance refers to that the s...

Embodiment 2

[0073] Embodiment 2, the present invention strain Lactobacillus rhamnosus WKA55 ( Lacticaseibacillus rhamnosus ) in the prevention and / or treatment of alcoholic liver injury

[0074] The examples in this group provide Lactobacillus rhamnosus WKA55 ( Lacticaseibacillus rhamnosus ) use in the prevention and / or treatment of alcoholic liver injury;

[0075] In a specific embodiment, the prevention and / or treatment of alcoholic liver injury includes anti-oxidation, improving the swelling state of the liver, inhibiting liver function damage, and improving lipodystrophy in vivo;

[0076] In a more specific embodiment, the antioxidant refers to scavenging hydroxyl radicals and scavenging DPPH;

[0077] In a more specific embodiment, said inhibiting liver function damage refers to reducing ALT and AST indexes;

[0078] In a more specific embodiment, the improving the swollen state of the liver refers to reducing the liver index value;

[0079] In a more specific embodiment, the imp...

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Abstract

The invention "Lactobacillus rhamnosus strain WKA55 and its use and product in preparing products for preventing and treating alcoholic liver damage" belong to the technical field of microorganisms. The present invention provides Lactobacillus rhamnosus WKA55 ( Lacticaseibacillus rhamnosus ) and its application in the prevention and / or treatment of alcoholic liver damage, and experiments have confirmed that Lactobacillus rhamnosus WKA55 has strong free radical scavenging ability, which can help the body to remove excess free radicals, improve antioxidant capacity, reduce liver damage. At the same time, it has strong adhesion ability of intestinal epithelial cells and improves intestinal barrier function.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and particularly relates to Lactobacillus rhamnosus strain WKA55 and its use and products in preparing products for preventing and treating alcoholic liver damage. Background technique [0002] Alcoholic liver damage, also known as alcoholic liver disease, is caused by long-term or heavy drinking, causing liver damage and causing liver disease. Alcoholic liver disease is a common liver disease. The main symptoms are alcoholic fatty liver disease, hepatitis, liver fibrosis, liver cirrhosis, and in more severe cases, it will deteriorate into liver cancer. Investigator Huang Shunling and others conducted an epidemiological and clinical investigation in Hunan Province and found that the rate of alcoholic liver disease was 4.36%, of which alcoholic liver cirrhosis was 0.68% and alcoholic hepatitis was 1.5%. Several studies have shown that alcoholic liver disease is associated with per capita a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P39/06A61P1/16A61P1/00A61P3/06A23L33/135C12R1/225
CPCA61K35/747A61P39/06A61P1/16A61P1/00A61P3/06A23L33/135A23V2002/00A23V2400/175A23V2200/3262A23V2200/32A23V2200/3204A23V2200/30Y02A50/30
Inventor 方曙光孔素芬朱明明左慧玉宋沙沙陈明阳
Owner JIANGSU WECARE BIOTECHNOLOGY CO LTD
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