Method for catalytically synthesizing 2, 5-furandicarboxylic acid by utilizing methylobacterium

Abstract

The invention discloses a method for catalytically synthesizing 2, 5-furandicarboxylic acid by utilizing methylobacterium, which comprises the following steps: taking 5-hydroxymethylfurfural as a substrate, and adopting methylobacterium extorquens AM1 as a whole-cell catalyst to react, so as to obtain the 2, 5-furandicarboxylic acid, the methylobacterium extorquens AM1 is used as the whole-cell catalyst, and the methylobacterium extorquens AM1 is used as the whole-cell catalyst to obtain the 2, 5-furandicarboxylic acid, the methylobacterium extorquens AM1, the methylobacterium extorquens AM1 and the 2, 5-furandicarboxylic acid. The methylobacterium extorquens AM1 is preserved in the American standard biological product collection center, and the preservation registration number of the methylobacterium extorquens AM1 is ATCC (American Standard Biological Collection Center) 14718. The 2, 5-furandicarboxylic acid is produced by the method, the 2, 5-furandicarboxylic acid can be obtained by directly converting the substrate 5-hydroxymethylfurfural through whole cells, and the method has the characteristics of simplicity in operation, low cost, pollution reduction and the like, and has a good industrialization prospect.

Description

A kind of method that utilizes methylobacter to catalyze and synthesize 2,5-furandicarboxylic acid technical field The present invention relates to technical field of bioengineering, relate in particular to a kind of utilization of methylobacter catalyzed synthesis 2,5-furan two formic acid method. Background technique 2,5-furandicarboxylic acid (2,5-furandicarboxylic acid, FDCA) is an important biological Taiwan compounds, whose most potential use is as a substitute for terephthalic acid (PTA) for the synthesis of renewable poly-2, Ethylene 5-furandicarboxylate (PEF) is widely used in the production of various bio-based polymers (such as polyamides, esters and polyurethanes, etc.). At present, chemical synthesis methods are mainly used, usually 5-hydroxymethyl furfural (HMF) is used as raw material, and precious metals are used. The catalyst is oxidized by O at high temperature and high pressure 2 Oxidation to prepare FDCA. It is mainly divided into two step...

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Problems solved by technology

[0004] At present, there is no report on the use of Methylobacterium and similar one-carbon microorganisms to produce 2,5-furandicarboxylic acid using 5-hydroxymethylfurfural as a substrate

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