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Bone tissue engineering shape-divided stent construction method

A technology of bone tissue engineering and construction method, which is applied in the field of biomedical materials and can solve problems such as the lack of gradient pore changes

Active Publication Date: 2022-06-21
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The embodiment of the present invention provides a method for constructing a fractal scaffold for bone tissue engineering to at least solve the technical problem that the gradient pore change is relatively lacking when the existing scaffold is constructed

Method used

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  • Bone tissue engineering shape-divided stent construction method
  • Bone tissue engineering shape-divided stent construction method
  • Bone tissue engineering shape-divided stent construction method

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Embodiment 1

[0049] According to an embodiment of the present invention, a method for constructing a fractional scaffold for bone tissue engineering is provided, see figure 1 , including the following steps:

[0050] S101: Obtain the physical geometric size of the target bone substitute;

[0051] S102: Determine a 2D fractal tree curve according to the physical geometry of the target bone substitute;

[0052] S103: construct a 2D fractal layer by performing a circular array on the 2D fractal tree curve with the axis of the target bone defect;

[0053] S104: Design a 2D concentric ring curve at the bifurcation position of the 2D shape tree curve, and use the 2D concentric ring curves of different diameters to form a 2D ring layer;

[0054] S105: Create a 3D fractal layer and a 3D annular layer according to the diameter of the tow and the height of the target bone substitute, and the 3D fractal layer and the 3D annular layer are stacked axially layer by layer to construct a bone tissue eng...

Embodiment 2

[0141] A storage medium storing program files capable of implementing any one of the above-mentioned methods for constructing a fractional scaffold for bone tissue engineering.

Embodiment 3

[0143] A processor is used for running a program, wherein when the program is running, any one of the above-mentioned methods for constructing a fractional scaffold for bone tissue engineering is executed.

[0144] The above-mentioned serial numbers of the embodiments of the present invention are only for description, and do not represent the advantages or disadvantages of the embodiments.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a bone tissue engineering shape-divided scaffold construction method. The method comprises the following steps: acquiring physical and geometric dimensions of a target bone replacement; determining a 2D fractal shape tree curve according to the physical and geometric dimensions of the target bone replacement; performing circumferential array on the 2D fractal shape tree curve along the axis of the target bone defect to construct a 2D fractal layer; designing 2D concentric circular ring curves at the bifurcation positions of the 2D fractal shape tree curves, and forming a 2D circular ring layer by using the 2D concentric circular ring curves with different diameters; on the basis of the 2D fractal layer and the 2D circular ring layer, creating a 3D fractal layer and a 3D circular ring layer according to the diameter of the tow and the height of the target bone substitute; and the three parts are axially stacked layer by layer to construct the bone tissue engineering shape-divided stent. According to the invention, the technical problem that the radial gradient pore change of the existing stent is lacked when the existing stent is constructed is solved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for constructing a bone tissue engineering fractional scaffold. Background technique [0002] Critical bone defect is one of the important problems in today's orthopaedics, which seriously affects people's health and quality of life. Although autologous bone grafting has been the gold standard of treatment, the amount of available bone has limited its widespread clinical application. In this context, tissue engineering was proposed in 1987 with the aim of obtaining artificial substitutes for tissue replacement and regeneration. An ideal bone scaffold (material) should have biological activity, mechanical support, permeability and biodegradability. Among them, the interconnected porous structure can effectively promote cell proliferation and ingrowth and transport of nutrients and oxygen, and promote tissue regeneration. [0003] In order to simulate the g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/56A61F2/30B33Y10/00B33Y80/00
CPCA61L27/18A61L27/56A61F2/30942B33Y80/00B33Y10/00A61F2002/30948A61F2250/0023A61L2430/02C08L67/04Y02P10/25
Inventor 阮长顺屈华伟
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI