Probiotic composition with effects of thrombolysis, blood fat reduction and intestinal flora regulation and preparation method of probiotic composition

A technology for regulating intestinal flora and lowering blood lipids, applied in the field of probiotics, can solve the problems of inactivation of probiotics, lack of pertinence, and difficulty in improving the effect of intestinal flora, so as to reduce blood lipid levels and inhibit fat absorption Effect

A technology for regulating intestinal flora and lowering blood lipids, applied in the field of probiotics, can solve the problems of inactivation of probiotics, lack of pertinence, and difficulty in improving the effect of intestinal flora, so as to reduce blood lipid levels and inhibit fat absorption Effect

CN114680338APending Publication Date: 2022-07-01安徽燕婉健康科技有限公司
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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Disclosed are a probiotic composition with the functions of thrombolysis, blood lipid reduction, and intestinal flora regulation, and a preparation method thereof. A probiotic composition with the effects of thrombolysis, blood lipid lowering, and intestinal flora regulation, including reducing the content of reduced glutathione by inhibiting the increase in the content of related biological substances in the process of lipid metabolism and cholesterol metabolism. Lactobacillus acidophilus and Lactobacillus casei that regulate serum cholesterol levels;

[0025] Lactobacillus acidophilus includes: Lactobacillus acidophilus ATCC4356, which inhibits intestinal absorption of cholesterol by regulating the expression of peroxisome proliferator-activated receptor alpha (PPARα) and the key gene LXRα for adipocyte differentiation; Expression of SREBP2 and LDLR genes, inhibiting fat absorption and reducing NS1 acidophilus induced by high-fat diet;

[0026] The composition also i...

Embodiment 2

[0037] A preparation method of a probiotic composition with the effects of thrombolysis, blood fat reduction and intestinal flora regulation, comprising the following steps:

[0038] Step 1: Extraction of strains: Take out pure Lactobacillus casei, Lactobacillus acidophilus ATCC4356, Lactobacillus acidophilus NS1 and Bifidobacterium from the extremely cold liquid nitrogen refrigerator;

[0039] Step 2: Fermentation Amplification: In a sterile state, each bacterial species in step 1 is transferred to the respective independent inactivated culture medium, and then the medium is transferred to the intermediate fermenter, so that each bacterial species can be carried out. self-propagation;

[0040] Step 3: Preliminary Homogeneous Concentration: Using a mild process, the bacterial cells are concentrated 30 times to reduce shear force and air mixing;

[0041] Step 4: strain freezing and granulation: the concentrated strain is quickly frozen into small pellets;

[0042] Step 5: Fre...

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Abstract

The invention relates to the technical field of probiotics, and discloses a probiotic composition with the effects of thrombolysis, blood fat reduction and intestinal flora regulation, and the probiotic composition comprises lactobacillus acidophilus and lactobacillus casei; wherein the lactobacillus acidophilus is prepared from ATCC4356 lactobacillus acidophilus and NS1 lactobacillus acidophilus; the composition also comprises natto freeze-dried powder containing nattokinase. According to the scheme, the lactobacillus acidophilus and the lactobacillus casei are used for regulating and controlling the serum cholesterol level by inhibiting the increase of the content of related biological substances in the lipid metabolism and cholesterol metabolism processes and reducing the content of reductive glutathione; the cholesterol in the intestinal tract is degraded, absorbed and inhibited, so that the content of blood fat is reduced, and the intestinal flora is regulated and controlled by matching with bifidobacteria and directly conveying to the intestinal tract position by using the enteric capsule.

Description

technical field [0001] The invention relates to the field of probiotics, in particular to a probiotic composition with the functions of thrombolysis, blood fat reduction, and intestinal flora regulation, and a preparation method thereof. Background technique [0002] Probiotics are a class of active microorganisms that are beneficial to the host by colonizing the human body and changing the composition of the flora in a certain part of the host. By regulating the immune function of the host mucosa and system or by regulating the balance of intestinal flora, promoting nutrient absorption and maintaining intestinal health, resulting in the production of single microorganisms or mixed microorganisms with a clear composition that are beneficial to health. [0003] After research, probiotics have a certain effect on reducing blood lipids and blood clots, but only targeted probiotics can produce effects, and the extensive use of various probiotics cannot achieve this effect. It n...

Claims

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Application Information

Patent Timeline
01 Jul 2022
Publication
CN114680338A
IPC
A23L33/135; A23P10/30; A23L33/10; A23L11/50; A23L11/00; A23L7/104
CPC
A23L33/135; A23P10/30; A23L33/10; A23L11/50; A23L11/07; A23L7/104; A23V2002/00; A23V2400/125
Inventors
张正前