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Application of agilawood leaf water extract potent part in preparation of medicine for improving myocardial ischemia-reperfusion injury

A technology of reperfusion injury and water extract, which is applied in the field of medicine, can solve problems such as no relevant reports, expand the scope of medicinal use, and improve the effect of cardiomyocyte hypoxia/reoxygenation injury

Active Publication Date: 2022-07-15
DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the late start of research on Agarwood leaves, the current research on the biological activity and health effects of Agarwood leaves is still in the primary exploration stage. Regarding its function in treating myocardial ischemia / reperfusion injury and protecting the cardiovascular system and applications have not yet seen relevant reports

Method used

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  • Application of agilawood leaf water extract potent part in preparation of medicine for improving myocardial ischemia-reperfusion injury
  • Application of agilawood leaf water extract potent part in preparation of medicine for improving myocardial ischemia-reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of Agarwood Leaf Water Extract:

[0018] Soak 100 g of agarwood leaves in 3000 g of water for 30 min, reflux for 90 min, filter, repeat the reflux extraction 3 times, combine the filtrates, concentrate under reduced pressure, freeze-dry to obtain agarwood leaf water extract, numbered A.

Embodiment 2

[0020] Preparation of Agarwood Leaf Water Extract:

[0021] Soak 100 g of agarwood leaves in 1000 g of water for 40 min, reflux for 120 min, filter, repeat the reflux extraction 5 times, combine the filtrates, concentrate under reduced pressure, and freeze-dry to obtain agarwood leaf water extract, numbered B.

Embodiment 3

[0023] Preparation of Agarwood Leaf Water Extract:

[0024] Soak 100 g of agarwood leaves in 5000 g of water for 20 min, extract under reflux for 30 min, filter, repeat the reflux extraction twice, combine the filtrates, concentrate under reduced pressure, and freeze-dry to obtain agarwood leaf water extract, numbered C.

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Abstract

The invention discloses application of a potent part of agilawood leaf water extract in preparation of a medicine for improving myocardial ischemia reperfusion injury, and the potent part of agilawood leaf water extract is prepared by the following steps: soaking agilawood leaves in 10-50 times by mass of water for 20-40 minutes, carrying out reflux extraction for 30-120 minutes, filtering, repeatedly carrying out reflux extraction for 2-5 times, merging filtrates, and concentrating to obtain the potent part of agilawood leaf water extract. And performing column chromatography on macroporous adsorption resin with the model of HPD-100, eluting with water, concentrating under reduced pressure, and freeze-drying to obtain the potent part of the agilawood leaf water extract. Experiments prove that the potent part of the agilawood leaf water extract can remarkably relieve myocardial cell hypoxia / reoxygenation injury of rats, and is higher in activity and wider in safety range.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of a strong part of agarwood leaf water extract in preparing a medicine for improving myocardial ischemia-reperfusion injury. Background technique [0002] Medical research has found that in the process of ischemic disease treatment, after ischemic tissue or cells restore blood supply, excessive free radicals attack tissue cells that have regained blood supply, resulting in further damage to these tissue cells compared to ischemia. This injury is called "ischemia / reperfusion injury" and can cause further deterioration of organ function. Therefore, the development of drugs to improve ischemia / reperfusion injury is an indispensable part of the treatment of ischemic diseases. [0003] Ischemia / reperfusion injury is closely related to the occurrence and development of various diseases (H. Groot et al. Transplantation Proceedings, 2007, 39: 481-484; C. D. ...

Claims

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Application Information

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IPC IPC(8): A61K36/835A61P9/10A61K127/00
CPCA61K36/835A61P9/10A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/55
Inventor 林生夏桂阳商洪才夏欢卫晓红王玲燕张倩夏小凤吴雪芬
Owner DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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