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Traditional Chinese medicine composition for treating systemic inflammatory response after cardiac surgery

A post-surgical and drug technology, applied in the field of medicine and biology, can solve problems such as inaccessibility of beneficial substances and brain complications, and achieve the effects of relieving systemic inflammatory response, improving prognosis, and improving postoperative prognosis.

Pending Publication Date: 2022-07-22
李平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the central nervous system has complex vascular barriers, including blood-brain barrier and blood-cerebrospinal fluid barrier, under normal circumstances, the cerebrovascular barrier will restrict the macromolecules in the blood from entering the brain and maintain a stable environment in the brain tissue; but Some researchers have observed that in the acute stage of mouse colitis, the number of macrophages in the mouse brain increases, and at the same time, microglia, the main immune surveillance cells of the nervous system, are also activated, indicating that intestinal inflammation can Rapidly cause an inflammatory response in the brain; in the state of intestinal inflammation, harmful substances enter the blood, and the cerebrovascular barrier senses this "threat", and chooses to close to prevent harmful substances from entering, maintaining the homeostasis of the brain, but isolating external communication, Harmful substances cannot enter, and neither can beneficial substances. At the same time, the metabolites produced in the brain cannot be transported out. At this time, brain complications occur.

Method used

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  • Traditional Chinese medicine composition for treating systemic inflammatory response after cardiac surgery
  • Traditional Chinese medicine composition for treating systemic inflammatory response after cardiac surgery
  • Traditional Chinese medicine composition for treating systemic inflammatory response after cardiac surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1. LXHCF treatment can significantly reduce the inflammatory response caused by AMI in model mice

[0077] One day after AMI modeling, WBC, MON, NEUT, MON%, NEUT% of each group

[0078] There was no significant change in the total number of white blood cells (WBC), the total number of monocytes (MON), the total number of neutrophils (NEUT), the percentage of monocytes (MON%) and the percentage of neutrophils (NEUT%).

[0079] The results of testing 3 days after surgery showed:

[0080] (1) Compared with the sham operation group, the content of WBC, MON and NEUT in the model mice increased significantly (P<0.05, 0.01).

[0081] (2) Compared with the model group, LXHCF-L significantly reduced WBC, MON, NEUT, and MON% of the model mice after surgery (P<0.05, 0.01), and the reduction rates were 37.8%, 82.5%, 50.3%, and 70.6%, respectively. ;

[0082] (3) The antibiotic group had no significant effect on WBC, MON, NEUT, MON% and NEUT% of the model mice;

[0083] ...

Embodiment 2

[0088] Example 2. LXHCF treatment can significantly reduce the expression of CRP and IL-6 in AMI model mice

[0089] Three days after the operation, the CRP and IL-6 levels of the mice in each group were detected according to the aforementioned methods. The results showed that:

[0090] (1) Compared with the sham operation group, the plasma CRP of the mice in the model group was significantly increased (P<0.01);

[0091] (2) Compared with the model group, the antibiotic group had no significant effect on the CRP level of the model mice,

[0092] (3) LXHCF-H, LXHCF-L, antibiotics + LXHCF significantly decreased the level of plasma CRP in model mice (P<0.05, 0.01).

[0093] 7 days after the operation, further tests were carried out, and the results showed that,

[0094] (1) Compared with the sham operation group, there was no significant difference in CRP in the model group;

[0095] (2) Compared with the model group, LXHCF-L still significantly reduced the plasma CRP level o...

Embodiment 3

[0097] Example 3. After administration of LXHCF, the pathological state of myocardial tissue in AMI model mice was significantly improved

[0098] After the administration, in order to further observe the improving effect of LXHCF on myocardial histopathology, the heart tissue was stained with H&E according to the aforementioned method. The results show,

[0099] (1) The model group showed focal degeneration and necrosis of the myocardium, myocardial atrophy, rupture, accompanied by inflammatory cell infiltration, fibroblast proliferation and early myocardial fibrosis;

[0100] (2) Focal degeneration and necrosis of the myocardium in the antibiotic group, myocardial atrophy, rupture, and infiltration of inflammatory cells, but no significant improvement;

[0101] (3) LXHCF-H, LXHCF-L, Antibiotic+LXHCF attenuates cardiac inflammatory response to different degrees, reduces inflammatory cell infiltration, and improves histopathological abnormalities in model mice.

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Abstract

The invention relates to a traditional Chinese medicine formula for treating systemic inflammatory response after cardiac surgery. The traditional Chinese medicine formula is a prefabricated traditional Chinese medicine granule formula and comprises the following components: black prepared common monkshood daughter root, dried ginger, pulp of dogwood fruit, coptis chinensis, wine-processed rhubarb, salvia miltiorrhiza, angelica sinensis, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, fructus aurantii, mangnolia officinalis, pericarpium citri reticulatae, poria cocos, herba lycopi, radix clematidis, sargentgloryvine stem and cinnamon.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a traditional Chinese medicine prescription for treating systemic inflammatory reaction after cardiac surgery. Background technique [0002] Cardiac surgery is an effective therapeutic intervention in the treatment of cardiovascular disease, however, it faces the problems of high trauma, postoperative complications and mortality. One of the main reasons is that cardiac surgery can lead to systemic inflammatory response syndrome (SIRS). effect; SIRS is thought to be closely associated with increased perioperative morbidity and mortality. Preoperative inflammation-related complications, surgical trauma, cardiopulmonary bypass, and intraoperative ischemia-reperfusion injury are closely related to the occurrence of SIRS. At present, some studies have tried some anti-inflammatory drugs to deal with systemic inflammatory response, but the clinical effects of ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61P29/00A61P9/00
CPCA61K36/714A61K36/9068A61K36/40A61K36/718A61K36/708A61K36/537A61K36/232A61K36/284A61K36/752A61K36/575A61K36/076A61K36/53A61K36/716A61K36/486A61K36/48A61K36/185A61K36/54A61K9/16A61P29/00A61P9/00A61K2300/00
Inventor 李平
Owner 李平
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