Compound granule as well as preparation method and application thereof

A granule and compound technology, applied in the field of medicine, can solve problems such as limited mass production and inconvenience, and achieve the effects of increasing medication compliance, promoting healing, and reducing ulcer area.

Pending Publication Date: 2022-07-29
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coptidis Rhizoma Powder is used as the powder, wrapped in cotton, and contains throat juice, which is inconvenient; if it is made into a decoction and taken, it is also subject to restrictions in carrying, transportation, storage, etc., which limits mass production

Method used

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  • Compound granule as well as preparation method and application thereof
  • Compound granule as well as preparation method and application thereof
  • Compound granule as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] A second aspect of the present application provides a method for preparing the compound granules of the first aspect of the present application, comprising:

[0028] Take the Coptis Cohosh extract, add the diluent, the flavoring agent and the wetting agent, mix uniformly to prepare a soft material, sieve and granulate, and dry to obtain the compound granules.

[0029] In the present application, the amount of the wetting agent added is not particularly limited, as long as the purpose of the present application can be achieved; in the process of making the soft material, the amount of the wetting agent added is sufficient to make the soft material The compound granules of the present application can be shaped by holding them into a ball and pressing lightly to disperse.

[0030] The inventors have found that the preparation method of the compound granules of the present application has good stability, and the preparation method is simple and convenient, so that the compo...

preparation example 1

[0041] Preparation Example 1 Preparation of Compound Granules

[0042] Take crude medicine: 16g of cohosh and 8g of Coptis chinensis, add water for 3 times, add 240mL of water each time, soak for 3h before the first decoction, decoct for 100min each time, filter with gauze, combine the filtrate, and concentrate on a rotary evaporator to obtain 8mL Coptis Cohosh extract (equivalent to 3g crude drug / mL); take Coptis Cohosh extract, add 14g dextrin, 0.28g aspartame and a suitable volume of 90vol% ethanol aqueous solution to wet, and mix well to make a soft material , pass through an 18-mesh sieve for granulation, dry in a constant temperature blast drying oven at 40-50°C for 40 minutes, gradually heat up, turn it in time, avoid agglomeration, and granulate to obtain compound granules. The prepared compound granules are yellow granules, with a sweet and slightly bitter taste and a slightly sweet smell.

[0043] Quality Evaluation of Compound Granules

[0044] Analysis of isofe...

Embodiment 1

[0071] Example 1 The effect of compound granules on the growth of oral ulcer rats

[0072] The above-mentioned experimental animal model and grouping were used to monitor the spirit and activity of each group of rats during the continuous administration process, record the daily body weight of the rats, and use the weight ratio change rate to evaluate the body weight change, the weight ratio change rate = (final Body weight-initial body weight) / initial body weight × 100%; it was observed that the rats in the control group were in good mental condition, were sensitive, moved freely, and had shiny fur; the rats in the model group had decreased postoperative food intake and water intake, gradually lost weight, and had Weakness; rats in each administration group (low-dose granule group, high-dose granule group, Yuanfang group and Bingboran powder group) also had decreased food intake and water intake, body weight loss, and lethargy, but the degree was higher than that of the model ...

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Abstract

The invention provides a compound granule and a preparation method and application thereof, the compound granule comprises coptis chinensis, cimicifuga foetida, a diluent, a flavoring agent and a wetting agent; wherein the mass ratio of the rhizoma coptidis to the rhizoma cimicifugae is 1: (1.8-2.2), the rhizoma coptidis and the rhizoma cimicifugae are provided in the form of rhizoma coptidis and rhizoma cimicifugae extract, the ratio of the volume of the rhizoma coptidis and rhizoma cimicifugae extract to the mass of the diluent is 1mL: (1.5-2) g, and the mass ratio of the diluent to the flavoring agent is 1: (0.01-0.03). The compound granule provided by the invention has a better effect of treating oral ulcer, the preparation method is simple, the stability is good, the medicine cost is low, the compound granule is suitable for mass production, the transportation and carrying convenience of the medicine can be improved, and the medicine taking compliance of a patient can be improved.

Description

technical field [0001] The present application relates to the technical field of medicine, in particular to a compound granule and its preparation method and use. Background technique [0002] Oral ulcer is a common disease that can occur in any part of the oral mucosa, and is more common in the lips, cheeks and tongue. It has the characteristics of periodic recurrence, and is often accompanied by obvious pain, which seriously affects the patient's eating, speech, and oral hygiene. and mood, etc.; its pathogenesis is not clear, it may be related to many factors such as vitamin and trace element deficiency, virus and bacterial infection. Clinically, Western medicine is mainly to supplement vitamins or use glucocorticoids to reduce mucosal inflammation and reduce ulcer tissue damage. However, long-term use of such drugs may cause drug dependence and adverse reactions. Traditional Chinese medicine treatment of oral ulcers has few side effects and is effective. At present, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/16A61P1/02
CPCA61K36/718A61K36/71A61K9/1652A61P1/02A61K9/1623A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 王萌任晓亮张恺张德芹刘亚男曹世杰崔英赵鑫李娜周振宇梁腾辉余璇
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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