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Devices and methods for modulating immune system activity and treating cancer in cancer patients

An immune system, cancer technology, applied in the fields of therapy, electrotherapy, physical therapy, etc., can solve problems such as hindering the control of inflammatory state

Pending Publication Date: 2022-07-29
艾奧塔生物科技公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, most drugs act with peak and trough bioavailability after administration, which prevents sustained control of inflammatory state

Method used

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  • Devices and methods for modulating immune system activity and treating cancer in cancer patients
  • Devices and methods for modulating immune system activity and treating cancer in cancer patients
  • Devices and methods for modulating immune system activity and treating cancer in cancer patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0260] Embodiment 1. A method of modulating the immune system of a subject with cancer, comprising:

[0261]The splenic nerve of the subject is electrically stimulated using a fully implanted device comprising one or more electrodes in electrical communication with the splenic nerve sufficient to modulate the immune system of the subject.

Embodiment approach 2

[0262] Embodiment 2. The method of Embodiment 1, further comprising identifying a subject with cancer.

Embodiment approach 3

[0263] Embodiment 3. A method of treating cancer in a subject, comprising:

[0264] Electrically stimulating the splenic nerve of the subject using a fully implanted device comprising one in electrical communication with the splenic nerve sufficient to modulate the subject's immune system and treat the cancer in the subject or multiple electrodes.

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Abstract

Described herein are methods and devices for monitoring or modulating the immune system of a subject having cancer, as well as methods and devices for treating cancer in a subject. The implanted device may electrically stimulate the spleen nerve of a subject for treatment of cancer, which may modulate the inflammatory system (e.g., e.g., e.g., splenic nerve). ) and / or activating or increasing the circulation of one or more immune cells (e.g., natural killer cells and / or cytotoxic T cells) by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and / or anti-inflammatory cytokines) in a subject and / or activating or increasing the circulation of one or more immune cells (e.g., natural killer cells and / or cytotoxic T cells). An implanted medical device includes two or more electrodes configured to electrically stimulate a spleen nerve, and may also include an ultrasound transducer configured to receive ultrasound waves and convert energy from the ultrasound waves into electrical energy to power the device.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application No. 62 / 916,703, filed October 17, 2019, the contents of which are incorporated herein by reference for all purposes. technical field [0003] Described herein are methods of modulating the immune system of a subject with cancer, as well as methods of treating cancer using an implanted device configured to electrically stimulate the splenic nerve. Implantable devices and systems for performing such methods are further described. Background technique [0004] The inflammatory status of cancer patients can significantly affect disease prognosis. The innate immune system, including natural killer (NK) cells, is normally activated in response to cancer cells as part of the body's natural inflammatory defense system. At the same time, anti-inflammatory agents administered to cancer patients have been found to be effective in the treatment of cancer in com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05A61N1/18A61N1/32A61N1/36
CPCA61N1/36002A61N1/0556A61N1/3787A61N1/37217A61N1/3606A61N1/36053A61N1/36135A61B5/01A61B5/024A61B5/021A61N1/36139A61N1/36157A61N1/36171A61N1/36178
Inventor J·M·卡梅纳M·M·马哈贝兹R·尼利J·凯伊G·蒙特罗·加尼尔
Owner 艾奧塔生物科技公司
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