Separation of metals using DOAT-based chelating agent chromatography
A chromatographic separation, metal technology, applied in the direction of solid adsorbent liquid separation, separation method, ion exchange, etc.
Pending Publication Date: 2022-07-29
NUCLEAR RES & CONSULTANCY GRP
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Problems solved by technology
Although the formation of highly stable complexes is essential for bifunctional chelators used in clinical or in vivo settings, this stabilization is critical when the chelator is used in a chromatographic separation process where removal of the chelator is required. sex is a disadvantage
Method used
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[0038] In the present invention, compounds of general formula (I) are used for the chromatographic separation of rare earth elements, actinides and / or s-, p- and d-block metals:
[0039]
[0040] in
[0041]
[0042] A is H, halogen (Cl, Br, F), SO 3 H.C 1-4 Alkyl, Aryl, Heteroaryl, C-O-C 1-16 a substituted N or C in alkylamino,
[0043] Z and Z 1 independently by H, halogen (Cl, Br, F), SO 3 H.C 1-4 Alkyl, Aryl, Heteroaryl, C-O-C 1-16 a substituted N or C in alkylamino,
[0044] E=O, S or P;
[0045] R 1 independently substituted or unsubstituted C 4-15 Alkylaryl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, or substituted or unsubstituted heteroaryl, wherein substitution is by one or more selected from the group consisting of Partially performed: imide, -C(O)(CH 2 ) 0-3 CH 3 , C 2-5 Carboxyl, -(CH 2 ) 1-3 C(O)(CH 2 ) 0-3 CH 3 , nitro, amino, thiol, succinimide, maleimide, aminooxy, acetylene, N 3 , acetamido, azide, ...
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The invention relates to the use of chelating compounds (I) for the chromatographic separation of rare earth elements, actinide elements and / or s-, p-and d-region metals, and to a method for the chromatographic separation of chelates of rare earth elements, actinide elements and / or s-, p-and d-region metals from a mixture of at least two metal ions. The method is characterized in that it comprises the following steps: (a) providing a mixture of at least two different metal ions selected from rare earth metal ions, actinide ions and / or s-, p-and d-region metal ions, (b) contacting the metal ions included in the mixture with at least one compound of general formula (I) of any one of the preceding claims to form a chelate; (c) subjecting the chelate from step (b) to chromatographic separation wherein optionally the at least one separated metal chelate obtained in step (c) can be subjected to at least one further chromatographic separation in order to increase the purity of the at least one separated metal chelate; and optionally, (d) obtaining the metal from the at least one isolated metal chelate. (I)
Description
technical field [0001] The present invention relates to the use of chelating compounds for the chromatographic separation of rare earth elements, actinides and / or s-, p- and d-block metals, and to the chromatographic separation of rare earth elements, actinides and / or s-, p- and chelates of d-block metals. Background technique [0002] Radionuclides have been used successfully in diagnostic applications for decades. Over the past decade, new compounds have been developed that target diseases very specifically, such as cancer. By combining these compounds with radionuclides, diseases such as cancer can be imaged, enabling accurate diagnosis as the basis for optimal treatment. The targeting precision of these compounds has now reached a level where radionuclides that have therapeutic effects by locally destroying tissues and cells can be employed, leaving healthy tissues and cells largely unharmed. With the development of more and more specifically targeted compounds, the c...
Claims
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Login to View More IPC IPC(8): C07D273/00C07D257/10B01D15/08A61K51/04
CPCC07D273/00C07D257/10B01D15/3828C07D471/08C22B3/22C22B59/00C22B60/02
Inventor 托马斯·詹考伯斯·玛丽亚·莫勒纳尔桑德·德·格罗特
Owner NUCLEAR RES & CONSULTANCY GRP