Preparation method of Xuanmai Gan orange granules

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation method of Xuanmaigangan granules. The preparation method of the Xuanmaigangan granules comprises the following steps: separately decocting and extracting radix scrophulariae to obtain a radix scrophulariae extracting solution, mixing and decocting radix ophiopogonis, liquorice and platycodon grandiflorum, extracting, mixing with the radix scrophulariae extracting solution, filtering, standing filtrate, concentrating, forming paste, adding auxiliary materials, and granulating, thereby obtaining the Xuanmaigangan granules. Wherein the medicinal materials are soaked before decoction and extraction, and medicine liquid is forced to circulate in the soaking process. According to the method disclosed by the invention, the material-liquid ratio, the dipping time, the boiling extraction temperature and pressure and the concentration temperature and pressure of the Xuanmaigangan particle extraction are controlled, and the traditional mixed extraction and water decoction mode is changed into the single water decoction extraction of the radix scrophulariae, so that the transfer rate of the harpagoside can reach more than 50% in the whole extraction production process, and is improved by more than 10% compared with that of the original process.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation method of Xuanmai Ganju granules. Background technique [0002] Xuanmai Ganji Granules is a kind of Chinese patent medicine which is a kind of Chinese patent medicine which is made of four kinds of herbs, including Scrophularia Radix, Ophiopogon japonicus, Licorice root and Platycodon grandiflorum. It is used for the effect of yin deficiency and fire, floating fire, dry mouth and nose, and sore throat. Scrophularia is a commonly used traditional Chinese medicine with a long history. Its chemical components mainly include iridoids, sesquiterpenes, triterpenes, simple phenylpropanoids, flavonoids, alkaloids, organic acids and polysaccharides. Harpagoside is a characteristic ingredient with high content in Scrophulariaceae, and it is also the basis of the main medicinal substances in Xuanmai Ganju Granules. White blood cel...

AI Technical Summary

Problems solved by technology

At the same time, harpagoside is a water-soluble substance with lively properties, which is easy to undergo acid-catalyzed hydrolysis reaction with other acid substances. The molecular structure is unstable and easy to degrade when heated, resulting in quality risks, high cost, and large waste of finished xuanmai ganju granules.

[0004] According to relevant knowledge about extraction of Chinese herbal medicines, if the transfer rate of active ingredients extracted from Chinese herbal medicines is less than 50%, it indicates that the extraction technology is poor, the consumption and waste of Chinese herbal medicines is large, and the production cost of Chinese herbal medicines is high. Breakthroughs will virtually bring pressure to the development of Chinese herbal medicines and even the Chinese patent medicine industry