Method for modeling skeletal muscle regeneration model under action of immune system

An immune system and model modeling technology, applied in biological systems, medical simulation, bioinformatics, etc., can solve problems such as accidental damage and recovery process of non-diseased muscle tissue, and skeletal muscle regeneration models cannot be simulated. The effect of accelerating muscle regeneration

Pending Publication Date: 2022-08-05
HARBIN UNIV OF SCI & TECH
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  • Summary
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  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the problem that the existing skeletal muscle regeneration model cannot simulate the accidental injury and recovery process of disease-free muscle tissue and that the existing skeletal muscle regeneration model does not take into account the regulation of immune cells and their secreted factors on muscle cells, and proposes A method for modeling skeletal muscle regeneration under the action of the immune system

Method used

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  • Method for modeling skeletal muscle regeneration model under action of immune system
  • Method for modeling skeletal muscle regeneration model under action of immune system
  • Method for modeling skeletal muscle regeneration model under action of immune system

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Experimental program
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specific Embodiment approach 1

[0011] Embodiment 1: A method for modeling a skeletal muscle regeneration model under the action of the immune system includes the following steps

[0012] Step 1: Establish a skeletal muscle regeneration model based on the accidental injury of human non-diseased muscle tissue and the subsequent recovery process;

[0013] Step 2: Based on the regulation of the immune system and its secreted factors on muscle cells, a skeletal muscle regeneration model based on the action of the immune system was established.

specific Embodiment approach 2

[0014] Embodiment 2: This embodiment is different from Embodiment 1 in that: the specific process of establishing a skeletal muscle regeneration model in the step 1 is as follows:

[0015] During skeletal muscle regeneration, six cellular interactions control the dynamic healing process: classically activated macrophages (P 1 ), alternately activated macrophages (P 2 ), satellite cells (S), myoblasts (M b ), healthy muscle fibers (M), and dead muscle fibers (M d ), each cell type represents a uniform concentration of nuclei within a given volume. The interaction between them is as figure 1 shown, the solid line represents the actual transfer of cells from one group to another, while the dashed line represents the interaction between two different cell populations;

[0016] Classically activated macrophages (P 1 ) with time, the ordinary differential equation is:

[0017]

[0018] In the formula, a 1 , a 2 , r 1 , d 1 represent the influx rate of classically activa...

specific Embodiment approach 3

[0034] Embodiment 3: This embodiment is different from Embodiment 1 or 2 in that: in the second step, based on the regulation of the immune system and its secreted factors on muscle cells, a skeletal muscle regeneration model based on the action of the immune system is established for:

[0035] During the regeneration of skeletal muscle under the action of the immune system, such as figure 2 shown, the immune cells involved in muscle regeneration are active neutrophils (N), lysed neutrophils (N d ), monocytes (P), classically activated macrophages (P 1 ), alternately activated macrophages (P 2 ). The affected muscle cells are satellite cells (S), myonuclei (M). b ), dead or damaged myonuclei (M d );

[0036] The ordinary differential equation of active neutrophils (N) over time is:

[0037]

[0038] In the formula, k 0 , d 0 represent the maximum rate of active neutrophil influx due to dead or damaged myonuclei, and the natural mortality of active neutrophils, res...

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Abstract

The invention provides a method for modeling a skeletal muscle regeneration model under the action of an immune system. The method comprises the following steps: step 1, establishing a skeletal muscle regeneration mathematical model based on a skeletal muscle regeneration ordinary differential equation; and 2, establishing a skeletal muscle regeneration model under the action of an immune system based on the regulation effect of the immune system and secreted factors thereof on muscle cells. The invention provides a mathematical description for the complex process of skeletal muscle regeneration based on the interaction between human in-vivo immunity and muscle cells, and has a theoretical guidance effect on the research of skeletal muscle regeneration mechanism and the treatment of skeletal muscle injury.

Description

Technical field: [0001] The invention relates to the field of biomedical engineering, in particular to a method for modeling a skeletal muscle regeneration model under the action of an immune system. Background technique: [0002] Skeletal muscle injury is an unavoidable and frequently encountered problem throughout a person's life. It can occur from a variety of causes, including sports contusions, myopathy, muscle overuse, and minor injuries from muscle tension. During normal aging, skeletal muscle damage, such as muscle atrophy and muscle weakness, can result from some of the pathologies that skeletal muscle may develop. Due to the combination of these internal or external factors, the muscles are in a more vulnerable state and a state of difficulty in regeneration. Likewise, certain physical activity is also associated with muscle regeneration. Therefore, understanding the processes involved in regeneration of skeletal muscle during development and aging, where regener...

Claims

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Application Information

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IPC IPC(8): G16B5/00G16H50/50G06F17/13
CPCG16B5/00G16H50/50G06F17/13
Inventor 王沫楠洪典
Owner HARBIN UNIV OF SCI & TECH
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