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Discrimination of hydrolysate in aconite injection

A hydrolyzate and injection technology, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of not being able to ensure the product, and can not really identify whether the aconitum injection contains hydrolyzate, etc., so as to achieve easy implementation and good identification effect Effect

Inactive Publication Date: 2005-01-12
贵州汉方制药有限公司
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  • Summary
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  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current identification method cannot really identify whether the hydrolyzed product is contained in the aconitum injection, and cannot ensure that the ex-factory product is the aconitum injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1. A new identification method for hydrolyzate in Aconitum injection is provided. It can effectively identify whether the sample really contains the hydrolyzate of aconitine, so as to ensure the factory quality of aconitine injection.

[0011] Technical scheme of the present invention. The method for identifying hydrolyzate in Aconitum injection is characterized in that it is carried out according to the following steps;

[0012] a. Make the test solution: take 5ml of the test solution of Aconitum injection, add ammonia to the test solution to make it alkaline, shake and extract 3 times with chloroform, 5ml each time, combine the chloroform solution, evaporate to dryness, add chloroform to the residue 1ml was dissolved to obtain the test solution, namely product A;

[0013] b, making reference substance solution: take reference substance aconitine, add water to make a solution containing 1mg per 1ml, and obtain reference substance solution, i.e. product B;

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Abstract

The pdiscrimination of hydrolysate in aconite injection includes compounding test sample solution, contrast solution and hydrolysate contrast solution; and subsequent thin-layer chromatography detection process based on Chinese Pharmacopoeia, i.e., dropping the three kinds of solution on the same thin silica gel board, developing with methanol-chloroform-ethyl ether developing agent, air drying, and spraying bismuth potassium iodide test solution. As the qualified product, the test sample has no spot in the position corresponding to that of the contrast solution chromatography and spot in the same color as the hydrolysate contrast solution in the corresponding position. The said method is used in the delivering discrimination of aconite injection product.

Description

technical field [0001] The invention relates to a method for identifying active ingredients in traditional Chinese medicine preparations, in particular to a method for identifying effective ingredients in Chinese medicine injections. Background technique [0002] At present, after the production of Aconitum Injection is completed, the identification method for whether the Aconitum Injection contains hydrolyzate (i.e. the active ingredient) is: take a sample of Aconitum Injection and instill dilute hydrochloric acid and place it in two test tubes. Infusion of mercuric potassium iodide test solution in one tube should form a white precipitate; another tube instillation of bismuth potassium iodide test solution should produce a brown precipitate. Those who meet the above requirements can meet the identification requirements. However, this identification method cannot effectively identify whether the sample actually contains the hydrolyzed product of aconitine. Because, if onl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
Inventor 邓杰龙险峰张明江唐修静王霞向勇唐云
Owner 贵州汉方制药有限公司