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Medicine compound contg. troxeration

The technology of troxerutin and composition is applied in the field of immediate-release composition containing troxerutin and its preparation, and can solve the problems of limited clinical application of troxerutin, slow disintegration and dissolution of tablets, and delayed dissolution time. And other issues

Inactive Publication Date: 2006-02-22
管建立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, oral dosage forms such as powders, tablets, and capsules are widely used, but they all have certain defects. However, it is inconvenient to take; while coated tablets use polymers, gums, sugars, insoluble sunscreens and pigments in their formulations, and the dissolution time is often delayed.
The above-mentioned shortcomings greatly limit the clinical application of troxerutin, for example, due to the slow disintegration and dissolution of the tablet, it is not suitable for emergency treatment of cerebral embolism, cerebral apoplexy, cerebral hemorrhage or myocardial infarction; tablets and capsules are not suitable for Specific groups of people (such as the elderly, patients with dysphagia) administration, etc.
However, the corresponding solutions are not clearly taught in the prior art

Method used

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  • Medicine compound contg. troxeration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] prescription composition

[0017] Preparation process: Feed according to the amount of 1000 grains, and sieve 80 meshes before mixing the main ingredients. Mix the main drug and auxiliary materials evenly according to the proportion; transfer to the chemotherapy tank, heat the chemotherapy tank to make the chemical material temperature 95°C; transfer the medicine solution to the dripping pill machine, and maintain the temperature of the medicine solution (dropping temperature) at 90°C; start Dropping, the condensing medium is liquid paraffin, the temperature is 16°C; the distance from the dripper of the dropping pill machine to the condensate is 25cm. After the dripping is completed, filter and dry to obtain dropping pills.

Embodiment 2

[0019] prescription composition

[0020] Preparation process: Feed according to the amount of 1000 grains, and sieve 80 meshes before mixing the main ingredients. Mix the main drug and auxiliary materials evenly according to the proportion; transfer to the chemotherapy tank, heat the chemotherapy tank to make the temperature of the chemical material 100°C; transfer the medicine solution to the dripping pill machine, and maintain the temperature of the medicine solution (dropping temperature) at 90°C; start Dropping, the condensing medium is silicone oil, the temperature is 21°C; the distance from the dripper of the dropping pill machine to the condensate is 30cm. After the dripping is completed, filter and dry to obtain dropping pills.

Embodiment 3

[0022] prescription composition

[0023] Preparation process: Feed according to the amount of 1000 grains, and sieve 80 meshes before mixing the main ingredients. Mix the main drug and auxiliary materials evenly according to the ratio; transfer to the chemotherapy tank, heat the chemotherapy tank to make the temperature of the chemical material 100 °C; transfer the drug solution to the dripping pill machine, and maintain the temperature of the drug solution (dropping temperature) at 85 °C; start Dropping system, the condensing medium is liquid paraffin, the temperature is 18°C; the distance from the dripper of the dropping pill machine to the condensate is 30cm. After the dripping is completed, filter and dry to obtain dropping pills.

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Abstract

A composite medicinein the form of dripping pill contains troxeratin. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing troxerutin, in particular to an immediate-release composition containing troxerutin and a preparation method thereof. Background technique [0002] Soluble hydroxyethylated derivatives of rutin, Troxerutin, molecular formula C 33 h 42 o 19 ), is the main component of Venaoluton, its chemical name is 7,3',4'-trihydroxyethyl rutin, and its chemical structure is as follows: [0003] [0004] Troxerutin (Vinaorutong) is an active substance with a wide range of pharmacological activities, which can be used clinically to treat ischemic cerebrovascular diseases (such as cerebral thrombosis and cerebral embolism), cerebral apoplexy, cerebral hemorrhage, arteriosclerosis, Thrombophlebitis, myocardial infarction; at the same time, it can resist vascular injury caused by 5-hydroxytryptamine bradykinin, increase capillary resistance, reduce capillary permeability, and is clinically used to trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/20A61K9/28A61K47/34A61P9/10A61K47/10
Inventor 管建立
Owner 管建立