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Clindamycin metronidazole vagina effervescent tablet and its preparing method and use

A technology of clindamycin and effervescent tablets, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., which can solve the problem of non-permanent foam, affecting the therapeutic effect of drugs, and drugs cannot fully reach the vagina and other problems, to achieve the effect of large foaming volume, favorable drug distribution, and easy normal activities

Inactive Publication Date: 2006-05-31
程月发 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The resulting vaginal effervescent tablet disintegrates quickly and has many foams, but there is a defect that the foam is not durable, and the medicine cannot fully reach the folds of the vagina, thereby affecting the therapeutic effect of the medicine

Method used

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  • Clindamycin metronidazole vagina effervescent tablet and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Clindamycin 1250g

[0035] Metronidazole 1000g

[0036] Tartaric acid 1240g

[0037] Sodium bicarbonate 1350g

[0038] Microcrystalline cellulose 600g

[0039] Hypromellose 140g

[0040] Starch 500g

[0041] Sodium Lauryl Sulfate 120g

[0042] Magnesium stearate 120g

[0043]An appropriate amount of 5% ethanol solution of polyvinylpyrrolidone is used for granulation. Make it into 10000 pieces.

[0044] Preparation method: Mix half of clindamycin, metronidazole, microcrystalline cellulose, starch, hypromellose, sodium lauryl sulfate and sodium bicarbonate according to the prescription amount, and mix with 5% polyvinylpyrrolidone granulate with ethanol solution, and dry at 50-60°C; mix evenly half the amount of clindamycin, metronidazole, microcrystalline cellulose, starch, hypromellose, sodium lauryl sulfate and tartaric acid according to the prescription amount, Granulate with 5% polyvinylpyrrolidone ethanol solution, dry at 50-60°C; mix the above two kinds of ...

Embodiment 2

[0046] Clindamycin 2500 parts

[0047] Metronidazole 2000 parts

[0048] Tartaric acid 1380 parts

[0049] Sodium bicarbonate 1500 parts

[0050] Microcrystalline cellulose 800 parts

[0051] Hypromellose 150 parts

[0052] Starch 600 parts

[0053] Sodium Lauryl Sulfate 200 parts

[0054] Magnesium stearate 180 parts

[0055] An appropriate amount of 5% ethanol solution of polyvinylpyrrolidone is used for granulation. Make it into 10000 pieces.

[0056] Preparation method: adopt the same method as in Example 1 to prepare. The tablet weight of the obtained vaginal effervescent tablet is about 0.98g / tablet.

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Abstract

The invention discloses a clindamycin metronidazole vaginal effervescent tablet and its preparation method and application. The vaginal effervescent tablets use clindamycin salts or esters thereof and metronidazole as active ingredients and are prepared through ordinary tablet processing methods. The feature of the present invention is that the effervescent tablets contain hydroxypropylmethyl Cellulose is used as a binder. Compared with conventional effervescent tablets, cellulose has a larger foaming capacity, finer, richer, and longer-lasting foam, which is conducive to full distribution of active pharmaceutical ingredients, longer storage time, improved drug efficacy, and a simple process. , the quality of the finished product is stable and suitable for industrial scale production.

Description

Technical field: [0001] The invention relates to a clindamycin compound, a clindamycin-metronidazole vaginal effervescent tablet, a preparation method thereof and an application in medical treatment. Background technique: [0002] Clindamycin is a lincomycin antibiotic with strong antibacterial activity and broad antibacterial spectrum. It has obvious antibacterial effect, and also has bactericidal effect on most anaerobic bacteria, chlamydia, mycoplasma, Plasmodium falciparum and Toxoplasma gondii. This product acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Clindamycin is generally a bacteriostatic drug, but it also has a bactericidal effect on highly sensitive bacteria at high concentrations. It is widely used clinically to treat infections caused by aerobic gram-positive bacteria and various anaerobic bacteria. [0003] Metronidazole is a metronida...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61K31/4164A61K9/20A61P15/02A61K9/46
Inventor 程月发王国勤周文艳盛四龙
Owner 程月发
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