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Daphnetin and arteannuin derivative compatible anti-malaria composition

A technology of artemether and daphnetin, applied in the field of compound antimalarial compositions, can solve problems such as decreased sensitivity

Inactive Publication Date: 2006-06-21
中国预防医学科学院寄生虫病研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies at home and abroad have proved that the antimalarial effect of artemether on chloroquine-resistant strains of Plasmodium beighei (P.berghei) is much stronger than that of artemisinin and dihydroartemisinin; but after being widely used, Some recent research results show that in vitro tests in Hainan, Yunnan and other places have shown that the sensitivity of some malaria parasites to artemisinin and its derivatives has shown a downward trend

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Weigh 10 grams of artemether, 100 grams of daphnetin, and an appropriate amount of medical starch, fully mix the above three raw materials and auxiliary materials, then add starch slurry to granulate, dry after granulation, and add 0.8 grams of magnesium stearate for lubrication agent, sieved, and then compressed into 1000 tablets to obtain tablets.

[0065] Or use the aforementioned capsule formula to fully mix the original and auxiliary materials (magnesium stearate is not needed when making capsules) and then pack them into capsules in equal amounts.

Embodiment 2

[0067] Weigh 20 grams of artemether, 120 grams of daphnetin, and an appropriate amount of medicinal starch, fully mix the above three raw materials and auxiliary materials, then add starch slurry to granulate, dry after granulation, and add 0.9 grams of magnesium stearate for lubrication agent, sieved, and then compressed into 1000 tablets to obtain tablets.

[0068] Or use the above-mentioned capsule formula to fully mix the raw materials and auxiliary materials, and then pack them into capsules in equal amounts.

Embodiment 3

[0070] Weigh 30 grams of artemether, 150 grams of daphnetin, an appropriate amount of medicinal starch, and 1 gram of magnesium stearate. The operation method is the same as in Example 1, and capsules can be made equally, and the method is the same as in Example 1.

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Abstract

The present invention provides one kind of compound antimalarial agent comprising daphnetin and artemisine derivative and the artemisine derivative is artemisia methyl ether, dihydroartemisine and arteannuin. The tablet and capsule compounded with the recipe of the present invention is ideal antimalarial agent, and pharmacological test proves its high killing effect on drug resisting malarial parasite and its relatively low toxicity.

Description

technical field [0001] The invention relates to a new formula for treating malaria, and more specifically provides a compound antimalarial composition mainly composed of daphnetin and artemisinin derivatives. Background technique [0002] Malaria is one of the important tropical diseases that seriously endanger the health of people in developing countries. Since Plasmodium falciparum became resistant to the main antimalarial drug chloroquine in the 1960s, chloroquine-resistant and even multidrug-resistant Plasmodium falciparum has been spreading worldwide. According to incomplete statistics, there are about 300-500 million clinical cases of malaria every year in the world, and 1.5-2.7 million people die from malaria. [0003] In the early 1970s, after Chinese scholars isolated the antimalarial drug artemisinin from the Chinese herbal medicine Artemisia annua, they successively partially synthesized effective derivatives such as artemether, artesunate and dihydroartemisinin....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/357A61P33/06
CPCY02A50/30
Inventor 倪奕昌王琴美
Owner 中国预防医学科学院寄生虫病研究所
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