Mucosal originated drug delivery system and animal applications
A drug, mucosal technology, applied in the field of mucosal bioadhesive systems, which can solve the problem of irritation to animals, animal owners and health care providers
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Embodiment 1
[0120] Embodiment 1 prepares TMDD matrix
[0121]Tables 1 and 2 list TMDD formulations prepared with different ratios of polyacrylic acid, polyisobutylene (PIB), polyisoprene (PIP) and XL-10,000. Polyisobutylene is commercially available from Exxon Chemical under the tradename VISTANEX(R) LMMH. A preferred polyacrylic acid is Carbopol 971P NF available from B.F. Goodrich. Carbopol 971P is lightly crosslinked to give a "fishnet" hydrated gel structure. In contrast, Carbopol 934P contains benzene and is more highly crosslinked to form a "fuzzball" gel structure. Polyisoprene (PIP) is commercially available from Goodyear Tire & Rubber Company under the tradename NATSYN(R) 2210. XL-10,000 is a precrosslinked butyl terpolymer rubber available from Miles, Polysar Rubber Division of Miles, Akron, OH.
[0122] The PIB was extruded with a conventional two-roll mill until a thin layer formed on the rolls. Then mix PIP or XL-10,000 into PIB until evenly distributed. Carbopol was ad...
Embodiment 2
[0128] The impact of embodiment 2 polymer ratio on drug release
[0129] Using antipyrene (molecular weight MW=188.2) as the test drug molecule, the effect of changing the ratio of recording polymer XL10,000 and polyisobutylene on the control of drug release was evaluated. Antipyrine was added to the polymer matrix at 2% w / w. Figure 7 It is shown that the total amount of drug released after the end of 4 hours decreases with increasing XL10,000 relative to the percentage of PIB. Figure 8 Showing the typical drug release profile seen in these formulations, also the incorporation of 8% w / w polyisoprene (PIP) did not significantly affect the drug release of Formulations T and U. So R and T and S and U behaved similarly in drug release kinetics; however, formulations R and T released more drug at all time points compared to S and U.
[0130] Such as Figure 5 As shown, PIP does affect how the patch adheres to the gingival tissue at all times. Preferred formulations for these ...
Embodiment 3
[0132] Example 3 Optimizing Therapeutic Response with Penetration Enhancers
[0133] A nonionic surfactant was incorporated into the TMDDs of Examples 1 and 2 as the penetration enhancer (PE) Lauricidin(R). The effect of Lauricidin(R) on systemic drug absorption was studied with the drug medetomidine. Table 3 lists the individual ingredients (in grams) of the four formulations. Each formulation is approximately 50 grams of material.
[0134] Table 3: Formulations of Lauricidin® TMD Patch
[0135] Material
Ⅰ
Ⅱ
Ⅲ
Ⅳ
PIB
16.0
14.0
16.6
16.0
XL10,000
4.0
3.5
4.2
4.0
971P
27.5
27.5
27.5
27.7
MED
2.5
2.5
1.25
2.5
LCN
0.5
2.5
0.5
0.25
[0136] PIB, polyisobutylene; XL10,000, Polysar:971P, Carbopol; MED, medetomidine; LCN, La...
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