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Constitution method of monkey hyperkinesia animal model

A technology of animal models and construction methods, applied in teaching models, educational tools, instruments, etc., can solve problems such as the difficulty of completely treating ADHD

Inactive Publication Date: 2002-11-20
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, there are still many unknowns in the pathological mechanism of ADHD, which needs to be further studied, especially at this stage, there is no ideal animal model of ADHD, which brings great difficulties to a thorough understanding of the pathological mechanism of ADHD and the complete treatment of ADHD

Method used

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  • Constitution method of monkey hyperkinesia animal model
  • Constitution method of monkey hyperkinesia animal model
  • Constitution method of monkey hyperkinesia animal model

Examples

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Embodiment Construction

[0018] The present invention is further described by the following examples.

[0019] Two juvenile macaques (Macaca Mulatta) were selected, females, about 2 to 3 years old, weighing about 2.2 kg and 2.5 kg, respectively; they had not been used in other experiments; they were raised in a single cage, and water and food were not limited.

[0020] 1. Brain surgery

[0021] The day before the operation, fully prepare all kinds of supplies during the operation, autoclave the surgical instruments, and irradiate ultraviolet rays in the operating room for about 30 minutes. The monkey fasted for about 12 hours before the operation, but was given plenty of water.

[0022] The monkey was anesthetized with ketamine (intramuscular injection, 3 to 5 mg / kg body weight, induced anesthesia) and sodium pentobarbital (intraperitoneal injection, 35 mg / kg body weight), and the head was fixed on the Narishige SN-2 stereotactic instrument. Use a pencil to make a marking line on the scalp of the surgical...

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Abstract

The invention belongs to the areas of the medical evaluation and detecting technique, particular relates to the modeling method for fitlering the medication to treat the disease of motion too much and for evaluating the method of monkey animal model for treating the said diseases. Idiosyncratic antagon (yohimbine) in minute quantities of a2 acceptor are injected to the local area of the monkey prefrontal lobe, in order to block out the function of the a2 acceptor. Inducing the disease by experimental media directly builds the animal model of the said disease. The model can be used to filter the medication and evaluate the method for treating the disease.

Description

Technical field [0001] The invention belongs to the technical field of medical evaluation and detection, and specifically relates to a method for constructing an animal model for screening drugs for treating ADHD and evaluating methods for treating ADHD. Background technique [0002] Attention-deficit hyperactivity disorder (ADHD) is a common clinical behavioral disease in children and adolescents, which mainly manifests as attention disorder, hyperactivity and impulsivity. The incidence of ADHD in school-age children is about 3% to 10%. ADHD children are unable to complete school classroom education due to distraction and hyperactive behavior, which seriously affects their mental development and growth. ADHD mostly occurs in the preschool period, some improve in the later adolescence, and some live in problems such as family, poor partnership, social isolation, drug abuse and other psychological problems. It is not difficult to see that ADHD can cause great harm to society, fami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/36
Inventor 李葆明马朝林徐开静
Owner FUDAN UNIV
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