Transdermal plaster of aryl propionic non-steroid antiphlogistic

Abstract

The present invention relates to medicine technology and is especially one kind of new preparation form. The transdermal plaster is noe kind of antiphlogistic containing Flubiprofen, Ketoprofen, Ibuprofen, Rosorolfen, Naproxan and other aryl propionic non-steroid. It has three parts including non-sticking layer, medicine layer and lining layer. The medicine layer incldues medicine dispersed in matrix, and the matrix consists of non-polar polymer and plasticizer and may contains tackifier, transdermal promoter and oxidant. It has accurate admistration amount, no stimulation to gastrointestinaltract, relatively higher local medicine density in the affected part and controllable medicine release.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a new dosage form of an aryl propionic acid non-steroidal anti-inflammatory drug—a transdermal patch. Background technique: [0002] Arylpropionic acid non-steroidal anti-inflammatory drugs, such as flurbiprofen, ketoprofen, ibuprofen, rosoprofen and naproxen, have antipyretic, analgesic and anti-inflammatory effects, and are widely used clinically For the treatment of arthritis, rheumatoid arthritis and chronic pain, etc., the commonly used dosage form of this type of drug is oral preparation. Due to the short half-life, it needs to be administered 3 to 4 times a day, and the side effects of the gastrointestinal tract are relatively large. Patients who need to take the drug for a long time Or gastric ulcer patients often cannot tolerate it. [0003] Transdermal preparations can avoid the gastrointestinal irritation of oral drugs, reduce the systemic blood concentration, and i...

AI Technical Summary

Problems solved by technology

[0002] Arylpropionic acid non-steroidal anti-inflammatory drugs, such as flurbiprofen, ketoprofen, ibuprofen, rosoprofen and naproxen, have antipyretic, analgesic and anti-inflammatory effects, and are widely used clinically For the treatment of arthritis, rheumatoid arthritis and chronic pain, etc., the commonly used dosage form of this type of drug is oral preparation. Due to the short half-life, it needs to be administered 3 to 4 times a day, and the side effects of the gastrointestinal tract are relatively large. Patients who need to take the drug for a long time Or gastric ulcer patients often cannot tolerate

[0003] Transdermal preparations can avoid the gastrointestinal irritation of oral drugs, reduce the systemic blood concentration, and increase the local drug concentration in the affected area, but the transdermal administration of aryl propionic acid NSAIDs Preparations such as ketoprofen are a gel preparation, which has defects such as uncertain dosage, inconvenient use and easy contamination of clothing

Transdermal patches can overcome the defects of gel preparations, but so far there is no report about arylpropionic acid NSAIDs made into transdermal patches