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Nano hydroxy apatite calcium supplementing agent

A technology of hydroxyapatite and calcium supplement, which is applied in the directions of hydroxy compound active ingredient, phosphorus compound active ingredient, aluminum/calcium/magnesium active ingredient, etc. Insufficient calcium content and other problems, to achieve good biological activity, high absorption rate, and the effect of facilitating absorption

Inactive Publication Date: 2003-01-22
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size is too coarse, generally in the order of μm, which is not conducive to the absorption of calcium by the human body; Chinese invention patent 98117505.8 uses calcium acetate, calcium lactate, calcium citrate, calcium gluconate, calcium threonate, and calcium for hydrocarbon oil Composite decalcifying agent has the disadvantage of insufficient calcium content, which cannot reach the dose of calcium supplementation; Chinese invention patent 93106178.4 uses marine biological oysters and shells as raw materials for calcium extracts. Although its production process is simple and low in cost, its products Contains environmental pollutants in the ocean, and its calcium content is insufficient and the particle size is too coarse to meet the body's absorption of calcium
Studies have proved that the highest bioavailability of various active calcium in the international market is only 30%; and the composition is complex, and compounded with certain ingredients that affect calcium absorption, such as oxalic acid; especially containing a large amount of calcium salts and being too alkaline, greater stomach irritation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Add 60 kilograms of hydroxyapatite with a particle size of 100 ± 5 nanometers into a mixer with a volume of 120 liters, then add 3 kilograms of citric acid, 4 kilograms of malic acid, 3 kilograms of starch, 3 kilograms of sugar, and 100 grams of strontium. 165 grams of fluorine, 150 grams of iron, 170 grams of zinc, and 50 grams of manganese are fully mixed, and then pressed into tablets using a tablet machine, with a tablet weight of 0.5 grams, to obtain the high-nutrition and high-curative effect nano-calcium of the present invention. The human body absorbs 85% of the nano-calcium with high nutrition and high curative effect of the present invention.

Embodiment 2

[0014] Add 65 kg of hydroxyapatite with a particle size of 30±5 nanometers into a mixer with a volume of 120 liters, then add 2 kg of citric acid, 3 kg of malic acid, 30 kg of starch, 100 grams of strontium, and 165 grams of fluorine, 150 grams of iron and 170 grams of zinc are fully mixed, and then pressed into tablets using a tablet forming machine, with a tablet weight of 0.5 gram, to obtain the high-nutrition and high-curative effect nano-calcium of the present invention. The human body absorbs 90% of the high-nutrition and high-efficiency nanometer calcium of the present invention.

Embodiment 3

[0016] Add 70 kg of hydroxyapatite with a particle size of 30±5 nanometers into a mixer with a volume of 120 liters, then add 2 kg of citric acid, 2 kg of malic acid, 14 kg of starch, 200 g of vitamin D, and 200 g of vitamin B, after 200 grams of vitamin C and 200 grams of vitamin E are fully mixed, use a tablet forming machine to press into tablets, with a tablet weight of 0.5 grams, to obtain the high-nutrition and high-curative effect nano-calcium of the present invention. The human body absorbs 92% of the high-nutrition and high-efficiency nanometer calcium of the present invention.

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Abstract

Hydroxy apatite is prepared into 5-800 nm size hydroxy apatite calcium supplementing agent with hydroxy apatite content of 5-80%. The calcium supplementing agent contains also organic acid, starch, sugar, vitamins and trace elements. It may be produced into various dosage forms, including oral liquid, injection, beverage, food additive, ion implanting transdermal preparation, etc. for meeting the requirement of different people.

Description

technical field [0001] The invention relates to a health product using nano-scale hydroxyapatite as a calcium supplement. Background technique [0002] Calcium is the most abundant and one of the most important mineral elements in the human body. It plays an important role in maintaining the normal functions of the human body such as breathing, nerves, digestion, endocrine, urinary, and immunity. [0003] Current medical research shows that no matter the third world, or developed countries such as the United States, Europe, and Japan, calcium deficiency is relatively serious. For Chinese residents, since the current daily diet is still mainly plant-derived food, the calcium contained in plant food is not easily absorbed by the human body. Calcium deficiency is very widespread and has become a very common social problem. There are 80 million people diagnosed with osteoporosis in my country; among the 95 million children under the age of 3 in the country, the incidence of cal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/07A61K31/355A61K31/375A61K31/593A61K33/06A61K33/16A61K33/24A61K33/26A61K33/30A61K33/32A61K45/06
CPCA61K33/26A61K33/06A61K31/355A61K31/07A61K9/1617A61K31/593A61K33/24A61K33/16A61K9/1623A61K33/32A61K33/30A61K31/375A61K9/1652A61K45/06A61P3/02A61K2300/00
Inventor 李景虹
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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