31results about How to "Improve biological efficacy" patented technology

This invention discloses a wood preservative composition for the supplemental or remedial treatment of in-service poles, posts, piling, cross ties and other wooden structures. The wood preservative composition comprises copper 8-hydroxyquinolate (oxine copper) in combination with a boron compound or a fluoride compound.

The invention provides an emulsion comprising: (a) a continuous phase; (b) a dispersed phase comprising an active compound (1); and (c) colloidal particles located at the interface between the continuous phase and the dispersed phase. These are particularly useful with one or more agrochemicals or food additives as an active compound.

The invention relates to a proliferation accelerant and application thereof, in particular to a fibroblast proliferation accelerant capable of promoting fibroblast proliferation and fibroblast extractand fibroblast extract freeze-dried powder prepared through fibroblasts. The proliferation accelerant comprises loofah saponin and/or momordica saponin. A loofah saponin and momordica saponin combined inducer is adopted for culture of skin fibroblasts, so that synthesis and secretion of bioactive substances derived from the skin fibroblasts are promoted effectively, content of active ingredientsin cell derivatives is increased, and production efficiency and biologic effect of the skin fibroblast derived cell derivatives.

Hydroxy apatite is prepared into 5-800 nm size hydroxy apatite calcium supplementing agent with hydroxy apatite content of 5-80%. The calcium supplementing agent contains also organic acid, starch, sugar, vitamins and trace elements. It may be produced into various dosage forms, including oral liquid, injection, beverage, food additive, ion implanting transdermal preparation, etc. for meeting the requirement of different people.

The invention discloses application of juglone in the treatment of human liver cancer, wherein the juglone can inhibit the proliferation and invasion of human liver cancer cells, can inhibit the growth of tumor cells in the treatment of human liver cancer, and can be used for preparing anti-tumor drugs; meanwhile, the invention also discloses an extraction method of the juglone, firstly, walnut green tangerine peel is dried and crushed, then the walnut green tangerine peel is leached with ethanol solution under the aid of double-frequency ultrasonic waves, and finally, the walnut green tangerine peel is purified by D101 resin to obtain a juglone pure product. The juglone has the advantages of inhibiting proliferation and invasion of HepG2 cells, inhibiting the growth of tumor cells in thetreatment of human liver cancer, and directly killing tumor cells and inhibiting the invasion. The method of extracting the juglone from walnut green tangerine peel is simple and easy. The yield and the biological efficacy of the juglone can be well preserved, and oxidative degradation of the juglone and the derivatives thereof can be prevented.

This invention discloses a wood preservative composition for the supplemental or remedial treatment of in-service poles, posts, piling, cross ties and other wooden structures. The wood preservative composition comprises a slow-release micronized copper compound in combination with a boron compound or a fluoride compound.

The invention relates to the field of medicines, and particularly relates to a folic acid sustained-release composition, a sustained-release preparation and application thereof. The invention providesthe folic acid sustained-release preparation, which adopts a gastric retention technology and can prolong the retention time of a folic acid preparation in the stomach to 6 hours or above. The sustained-release preparation has lower administration frequency than a common-release preparation, and the administration frequency is reduced from 2-3 times per day to once per day, so that the preparation has a faster 5-methyltetrahydrofolic acid level increase rate than a common folic acid common-release preparation unexpectedly, and the rat animal model shows that the dosage of the 5-methyltetrahydrofolic acid level of the same body can be reduced by about 50% compared with the common-release preparation. The sustained-release preparation can be used for patients who need to take folic acid fora long time, such as megaloblastic anemia caused by folic acid deficiency, hyperhomocysteinemia caused by folic acid deficiency, cerebral apoplexy prevention and myocardial infarction caused by hyperhomocysteinemia, depression and anxiety induced by folic acid deficiency and the like.

The invention discloses a method for producing a high-content salinomycin premix. The method comprises adding a flocculant to flocculate a salinomycin fermentation liquid, carrying out standing, removing the supernatant, collecting the floc, adding auxiliary materials into the floc, and carrying out drying and crushing to obtain salinomycin premix particles with salinomycin content of 50-80%. Through experiments, the type and content of the flocculant in the premix are found and the biological efficacy of the salinomycin premix is significantly affected. Nonionic polyacrylamide as a flocculantis added into the fermentation liquid at a concentration of 3.50 mg/mL. Through use of the bran excipients, the premix with 65% of salinomycin is prepared. The premix is used for the culture of ducklings and realizes the survival rate of 99% and daily gain of 71 g/d.

The invention relates to application of konjac polysaccharide degradation products KGM-1k and KGM-5k in preparation of a probiotic protective agent. The application comprises the following steps of: firstly, destroying the hydrogen-bond interaction among konjac polysaccharide molecules by adopting hydrogen peroxide, then degrading the konjac polysaccharide molecules by utilizing cellulase, and carrying out alcohol precipitation, separation and purification by 60% ethanol to prepare the konjac polysaccharide degradation products KGM-1k and KGM-5k components with uniform molecular weight. The application has the beneficial effects that the influence of the konjac polysaccharide degradation products KGM-1k and KGM-5k on the survival condition of probiotics under the storage conditions of simulated gastric juice, small intestinal juice, vacuum freeze drying and different storage temperatures (4 DEG C and 25 DEG C) is investigated for the first time; and results show that the konjac polysaccharide degradation products KGM-1k and KGM-5k can enhance the stress resistance of the probiotics, increase the viable count of the probiotics under the storage conditions of vacuum freeze drying and different storage temperatures and increase the survival rate of the probiotics in the digestive tract, so that the gastrointestinal fluid can be tolerated to enter the predetermined part of the intestinal tract to realize field planting, and the application has important significance for improving the biological effects of the probiotics.

The invention discloses a fusing protein of long-effective recombinant human exoerythrocytic growing factor, which is characterized by the following: connecting two or three same genes of exoerythrocytic growing factor through one or two sections; constructing mammal expression plasmid; transmitting the plasmid in the mammal cell to express; lengthening the reserving time in the biological body for protein; reducing drug feeding times; improving the clinic practical value.

The invention discloses an ixeris sonchifolia hance preparation with an anti-gout effect. Through the anti-gout effect of the ixeris sonchifolia hance preparation, the clinical indication of ixeris sonchifolia hance is increased, so that the ixeris sonchifolia hance preparation not only can be used for treating a coronary heart disease, cerebral thrombosis, angina pectoris, anti-tumor and the like, but also can be used for treating a gout disease. An ixeris sonchifolia hance extract is taken orally and by injection, has an obvious effect on a hyperuricemia model induced by sodium urate in miceand is close to an allopurinol positive control group in effect. The ixeris sonchifolia hance preparation disclosed by the invention has the benefits that the ixeris sonchifolia hance preparation isa pure traditional Chinese medicine preparation, is small in toxic and/or side effects, has a cardiovascular and cerebrovascular protection effect and is an ideal anti-gout drug.

The invention is applicable to the technical field of soft capsules, and discloses a tea leaf-sourced plant soft capsule shell. The tea leaf-sourced plant soft capsule shell is prepared mainly from 50-75wt% of a tea leaf extract, 0-10wt% of modified tea fiber, 3-15wt% of carboxymethylcellulose (CMC), 0-5wt% of hydroxypropylmethyl cellulose (HPMC), 1-10wt% of carrageenan, 0.01-5wt% of gellan gum and 10-30wt% of a plasticizer, is applicable to medicines, food, health products, daily chemical products, chemical products and other capsule products, and has no special application restriction. The invention further provides a preparation method of a tea leaf-sourced plant soft capsule. The preparation method comprises the following steps: preparing the tea leaf extract, preparing the modified tea fiber, preparing a gum solution and preparing a soft capsule to obtain the tea leaf-sourced plant soft capsule. The soft capsule shell contains a variety of active substances contained in tea leaves, and thus has pharmacological activity and a health-care efficacy; various physical and chemical indexes meet requirements of relevant standards; the soft capsule shell can also be processed by using the conventional gelatin capsule processing equipment, so that the equipment utilization rate is improved; raw materials are low in cost; and industrial production is easy to implement.

The invention relates to the technical field of feed additives, in particular to a sulfate organic microelement-free special feed additive for suckling piglets and a preparation method for the specialfeed additive. The special feed additive comprises the following raw materials in parts by weight: 30-80 parts of ferrous fumarate, 10-40 parts of zinc fumarate, 5-15 parts of manganese methionine, 5-15 parts of copper mothionine, 1-5 parts of pantothenic acid, 0.002-0.03 parts of calcium iodate, 0.001-0.03 parts of sodium selenite, 0.001-0.03 parts of cobalt methionine and 0.01-0.05 parts of compound vitamin. The special feed additive, prepared by employing the method, for the suckling piglets employs all-organic microelements, is free of sulfate ions, is also free of inorganic anions, is not bitter and astringent, has high product purity and good palatability, can maintain the balance of electrolytes of the piglets, effectively reduces the diarrhea rate of the piglets and meets the needs of growth of the piglets; and the feed additive is used in special feed for the piglets, and thus, the prepared feed has good palatability and a high absorption rate, effectively maintains the balance of electrolytes in intestinal tracts of the piglets, and can obviously increase average daily gain and reduce a feed conversion ratio.

The invention discloses a preparation technology for watermelon juice capable of improving immunity. The preparation technology comprises the steps of 1 pre-treatment, wherein seedless watermelons areselected, peeled and frozen, and after the watermelons are cut into pieces and frozen, the frozen watermelon pieces are placed in an additive solution containing mango peel extracts and aloe extractsand taken out for unfreezing; 2 juicing, wherein saccharose is sprayed to the surfaces of the thoroughly unfrozen watermelon pieces for preserving, then the preserved watermelon pieces are juiced, and filter residues and filter liquor A are obtained after vacuum extraction filtration; the filter residues and watermelon peels are mixed, smashed and subjected to ultrasonic dispersion, and after juicing and extraction filtration, filter liquor B is obtained; 3 compounding, wherein the filter liquor A is mixed with the filter liquor B, and then after ultrafiltration, sterilization and metal and microbiological detection, the watermelon juice capable of improving the immunity is obtained. The preparation technology has the advantages that the preparation technology is simple, not only are allthe effects of the watermelons utilized, but also the additional value and economic value of the watermelons are improved, and the watermelons have excellent health care effects of blood fat reductionand weight losing, can maintain dynamic balance of the organism oxidation and antioxidant system, remove redundant free radicals, and improve the organism phylactic power and immunity.

The invention discloses a copper sulfide/manganese dioxide composite material and a preparation method and application thereof. The copper sulphide/manganese dioxide composite material comprises copper sulphide, manganese dioxide coating the surface of the copper sulphide, and stem cell targeting peptide modified on the surface of the manganese dioxide. The copper sulfide/manganese dioxide composite material disclosed by the invention has the capabilities of promoting MSCs migration, resisting inflammation and chondrogenic differentiation, also has the activity of superoxide dismutase and catalase, and can improve the cell activity of MSCs in an RA oxidative stress microenvironment. And the stem cell targeting peptide on the surface can enhance the mesenchymal stem cell targeting capability of the material and enhance the stem cell engineering efficiency of the nano material. The mesenchymal stem cells engineered by the copper sulphide/manganese dioxide composite material can obviously enhance the cell migration, anti-inflammatory and chondrogenesis capabilities of the stem cells, especially the capabilities of resisting inflammatory environment and resisting the influence of ROS on the cells.

The invention relates to the technical field of antioxidants, and particularly relates to a composite antioxidant containing folic acid. The composite antioxidant containing folic acid comprises the following components: lipoic acid, folic acid compounds, vitamin C, sodium sulfite and/or sodium hydrogen sulfite, beta-carotene and ethylene diamine tetraacetic acid, and the invention has the advantage of remarkable antioxidant effect.

A herbicide formulation in the form of a microemulsion, with enhanced agricultural efficiency, that allows lower use of the active substance and has a lower environmental impact, with the active substance being present in its acid form and no need for chemical modification thereof to dissolve it in the water of the application solution, and which exhibits effectiveness synergies in tank mixtures with other active substances. The active substance comprises glyphosate, Imazapir, Imazapic, Picloram, and mixtures of active substances comprising glyphosate and 2,4-dichlorophenoxyacetic acid, glyphosate and Dicamba, and Picloram and 2,4-dichlorophenoxyacetic acid, said active substances being dissolved in a specially designed co-adjuvant generated using a specific combination of surfactants andsolvents. Tank mixtures of the products formulated using the specially designed co-adjuvant and the active substances Imazapir and Imazapic, or Picloram and 2,4-D, are also included in the scope of the invention.