Colorimetric artificial nose having array of dyes and method for artificial olfaction

An artificial nose and dye technology, applied in the direction of analyzing materials, measuring color/spectral properties, using chemical indicators for analysis, etc., can solve problems such as inability to detect various vapors and interference

Inactive Publication Date: 2003-07-16
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, general artificial noses require extensive signal conversion hardware and are susceptible to interference from water vapor
As mentioned above, a single porphyrin-based detector has been used to detect a single strong acid, but not many vapors

Method used

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  • Colorimetric artificial nose having array of dyes and method for artificial olfaction
  • Colorimetric artificial nose having array of dyes and method for artificial olfaction
  • Colorimetric artificial nose having array of dyes and method for artificial olfaction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Scanning is performed at different time intervals, and the red, green and blue values ​​of the new image are subtracted from the red, green and blue values ​​("RGB") of the original scan to obtain a color change pattern. Figure 4 The color change pattern of n-butylamine is shown in , where the color change pattern of the metalloporphyrin sensor array 16 is a function of the time of exposure to n-butylamine vapor. from exposure to N 2 The scan after 5 minutes minus the start scan was used as a control, as shown in the figure, which is a black reaction. then make N 2 9.3% of n-butylamine passed through the array and was scanned after 30 seconds, 5 minutes and 15 minutes. Subtracting the image (absolute value) of the red, green and blue value ("RGB") pattern yields the displayed color change pattern. Virtually all porphyrins are saturated after 30 seconds of exposure, producing a unique color fingerprint for each class of analyte, which is shown in Figure 4 middle. ...

Embodiment 3

[0076] Such as Figure 6 As shown, the arrays of the present invention generate translatable and reversible responses even to analyte mixtures of strong ligands such as pyridine and phosphite. The color change pattern of the mixture is different from that of either pure vapor. Such as Figure 6 As shown, this analyte pair exhibits good reversibility when the vapor mixture is cycled between the pure analyte poles, Figure 6 A two-component saturation reaction is shown for a mixture of 2-picoline ("2MEPY") and trimethyl phosphite ("TMP"). N that saturates both analytes 2 The gas streams are mixed at variable flow rates to obtain a vapor mixture. Expose the veneer first to N 2 in pure trimethyl phosphite vapor (scan A), then increase the mole fraction of 2-picoline until pure 2-picoline vapor is reached (scan C), then decrease the mole fraction of 2-picoline until Back to pure trimethyl phosphite vapor. Scanning at the same mole fraction of trimethylphosphite in both direc...

Embodiment 4

[0080] In our effort to understand the cause of the color change upon exposure to vapor, diffuse reflectance spectra of individual porphyrin spots were obtained before and after exposure to analyte vapor. The porphyrin solution was applied to the plates in 50 [mu]L aliquots and dried under vacuum at 50[deg.]C. The diffuse reflectance spectrum of the plate was then measured with a UV-visible spectrophotometer equipped with an integrating sphere. The unique spectral shifts observed upon exposure to analytes correlate well with those seen from solution coordination. For example, exposure of Zn(TPP) to ethanol and pyridine exhibits distinctive spectral shifts that are very similar to those obtained from ligand exposure in solution. Figure 7 Shown is a comparison of the spectral shift of Zn(TPP) exposed to ethanol and pyridine (py) in dichloromethane solution (A) and on a reversed-phase support (B). In A and B, the bands from left to right correspond to Zn(TPP), Zn(TPP) (C 2 h ...

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Abstract

The present invention involves an artificial nose (10) having an array (12) comprising at least a first dye and a second dye in combination and having a distinct spectral response to an analyte. In one embodiment, the first and second dyes are from the group comprising porphyrin, chlorin, chlorophyll, phthalocyanine, or salen. In a further embodiment, the first and second dyes are metalloporphyrins. The present invention is particularly useful in detecting metal ligating vapors. Further, the array (12) of the present invention can be connected to a wavelength sensitive light detecting device.

Description

[0001] This invention was made with Government support under Contract No. HL25934 awarded by the National Institutes of Health and DAAG55-97-1-2211 awarded by the Department of the Army. The government has certain rights in the invention. [0002] priority statement [0003] This application claims priority to US Patent Application 09 / 532,125, filed March 21, 2000, and US Patent Application 09 / 705,329, filed November 3, 2000. technical field [0004] The present invention relates to methods and devices for artificial olfaction, such as artificial noses, for the detection of odorous substances by visual display. Background technique [0005] Olfactory or vapor selective detectors (ie, "artificial noses") are currently highly desired in many fields. For example, there is a need for an artificial nose capable of detecting small amounts of odorous substances and / or odorous substances that are harmf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/27G01N21/78G01N31/22
CPCG01N21/78G01N21/272G01N31/22
Inventor 肯尼思·S·萨斯利克尼尔·A·拉科夫阿维吉特·森
Owner THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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