Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

85 results about "Spectral shift" patented technology

Qualitative analysis method for improving identification result on basis of near-infrared mode

The invention discloses a qualitative analysis method for improving an identification result on the basis of the near-infrared mode. The qualitative analysis method comprises the steps of (1) acquiring near-infrared spectral data of a sample and determining a modeling set and testing sets; (2) carrying out pretreatment, partial-least-square feature extraction and orthogonal-linear-identification feature extraction on the modeling set and the testing sets in sequence; (3) calculating a spectral transformation matrix between the modeling set and the testing sets by adopting a direct model transferring method, and correcting the remaining testing sets; (4) establishing a quantitative analysis model; and (5) carrying out quantitative identification on the remaining testing sets by utilizing the established quantitative analysis model. The qualitative analysis method disclosed by the invention is established on the basis of near-infrared quantitative analysis, and the orthogonal-linear-identification method which is used in multi-classification and two-classification problems is used in the feature extraction step; in addition, the testing sets can be corrected by the direct model transferring method, so that the model applicability caused by long-time spectral shift of the same instrument can be realized and the result of quantitative identification is improved.
Owner:INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI

Optically encoded particles, system and high-throughput screening

ActiveUS20070148695A1Amenable to in vivo diagnosticsBioreactor/fermenter combinationsPeptide librariesPorosityAnalyte
The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
Owner:RGT UNIV OF CALIFORNIA

Cascade long-period pohotonic crystal fiber grating temperature sensor

The invention relates to a cascade long-period pohotonic crystal fiber grating temperature sensor. A photonic crystal fiber is provided with a cladding consisting of periodically arrayed air holes; the cladding and a fiber core of the fiber are made of SiO2; a long-period grating with a certain period is written onto the fiber; the air holes of the cladding are filled with thermosensitive substances sensitive to temperature; the refractive indexes of the thermosensitive substances are less than the refractive index of the fiber core; and the total internal reflection photonic crystal fiber is formed. The effective refractive index of a coupled mode of the grating can be changed by controlling the temperatures of the thermosensitive substances, so that the resonant wavelength of a transmission spectrum of the grating is changed, the temperature variation is shown as spectral shift, and the wavelength-tunable temperature sensor is realized. As the bandwidth of the transmission spectrum of the single long-period grating is greater, the temperature sensitivity and the measurement precision of the transmission spectrum of the long-period grating are limited, and the sensor is transformed into a cascade long-period grating structure. The sensor achieves the tunable wavelength, the sensitivity is improved, and the sensor has a very large application prospect in the transduction field.
Owner:TIANJIN UNIVERSITY OF TECHNOLOGY

Identification method for authenticity of varieties of seeds on basis of near-infrared quantitative analysis

The invention discloses an identification method for the authenticity of the varieties of seeds on the basis of near-infrared quantitative analysis. The method comprises the steps of acquiring near-infrared spectral data of a seed sample and determining a modeling set and testing sets; carrying out pretreatment, partial-least-square feature extraction and linear-identification feature extraction on the modeling set and the testing sets in sequence; selecting a spectral correction set from the modeling set and the testing sets, calculating a transformation matrix between the modeling set and the testing sets; applying the transformation matrix to the remaining testing sets; establishing a quantitative analysis model by adopting a support vector machine method; and carrying out identification on the authenticity of the varieties of the remaining testing sets by utilizing the quantitative analysis model. The identification method disclosed by the invention is established on the basis of near-infrared quantitative analysis and has the advantages that due to a series of operations of spectral pretreatment, feature extraction, correction of the testing sets, modeling and identification and the like, a more stable near-infrared spectral analysis model is established, and the problem of model applicability caused by long-time spectral shift of the same instrument can be solved, so that the identification result is accurate.
Owner:INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI

Method for optical detection of an adjoining of a material component to a sensor material with the aid of biological, chemical or physical interaction and device for carrying out said method (variants)

Application: detection of binding of biological and / or chemical components of liquid or gaseous mixtures and solutions, which are of mainly biological origin and / or determine parameters of living activity of biological objects, to substances that bind the said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and / or chemical components. Essence: binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light. In the first variant, the signal is represented by a spectrum; the sensor layer is more than 10 mum thick and exceeds the maximal recorded wavelength by at least an order of magnitude; information about the binding being detected is obtained from analysis of a spectral shift of interference maximums and minimums. In the second variant, the light passes also a scanned Fabry-Perot interferometer; the recorded signal is a dependence of intensity of the resulting light upon changes of base of the scanned Fabry-Perot interferometer, in which maximums due to correlation of the spectral characteristics of interaction of the light with the sensor layer and interferometer are observed; information about the binding being detected is obtained from a shift of the said dependence along values of base. In the third variant, other interferometers are used, which are scanned due to a change of the path difference of interfering beams. The required technical result is to make measurement results independent from uncontrollable variations of intensity of the analyzed light in whole as well as in any part of its spectrum, any areas of the sensor layer, and, consequently, to increase accuracy of measurements and reliability of results, sensitivity and resolution with simultaneous reduction of the number of necessary operations, of labor input and cost of both single- and multi-channel variants including real-time registration.
Owner:PETR IVANOVICH NIKITIN

Delivery system in micellar form having modular spectral response based on enzyme-responsive amphiphilic peg-dendron hybrid polymers

The present invention relates to new molecular design that allows micelles to report their activation and disassembly by an enzymatic trigger. The molecular design is based on introduction of a labeling moiety selected from a fluorescent dye, a dark quencher, combinations of dyes or dyes/quenchers, and a fluorinated moiety (a 19F-magenetic resonance (MR) probe for turn ON/OFF of a 19F-MR signal) through covalent binding to the focal point of amphiphilic polymer-dendron hybrids with the labeling moiety. At the assembled micellar state, the dyes are closely packed and hence the probability for intermolecular interactions increases significantly, leading to alteration of the fluorescent properties (signal quench or shift) or the 19F-MR signal (OFF state) of the micelles. Upon enzymatic cleavage of the hydrophobic end-groups from enzyme-responsive dendron, the polymers become hydrophilic and disassemble. This structural change is then translated into a spectral change as dye-dye interactions are halted and the dyes regain their intrinsic fluorescent properties, or alternatively by turn ON the 19F-MR signal. The high modularity of the design allows the introduction of various types of dyes and thus enables rational adjustment of the spectral response. Two major types of responses are described: Turn-On/Off and spectral shift, depending on the type of labeling dye. The present invention further provides methods of use of the hybrid delivery system and to a kit comprising the same.
Owner:RAMOT AT TEL AVIV UNIV LTD

Proteorhodopsin mutants with improved optical characteristics

The present invention is directed to a proteorhodopsin mutant having improved optical characteristics. One improved optical characteristic is having a lower pH (pKrh) at which equal concentrations of the acidic and basic spectral form of the proteorhodopsin molecules are present. Another improved optical characteristic is having a smaller difference in maximum absorption wavelength between the basic and the acidic form. The mutant comprises a mutation in a conserved amino acid residue of a proteorhodopsin variant, which causes spectral shifts. A preferred mutation site is a conserved histidine residue at amino acid position 75 of Bac31A8, or position 77 of Hot75m1, or its equivalent position of a proteorhodopsin variant. Another preferred mutation site is a conserved arginine residue at amino acid position 94 of Bac31A8, or position 96 of Hot75m1, or its equivalent position of a proteorhodopsin variant.
Owner:DANISCO US INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products