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Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of medicinal materials in Chinese traditional medicine

A technology for infrared spectroscopy and fingerprint identification, which is applied in the field of multi-level macro-fingerprint identification by non-separation and extraction of infrared spectroscopy of Chinese medicinal materials, can solve the problems of inability to strictly control, lack, instability and reliability, etc., to accelerate the quality control process of traditional Chinese medicine, speed up The speed of modernization and internationalization, the effect of intuitive identification

Inactive Publication Date: 2003-10-08
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods lose the overall analysis, lose the originality and compatibility of the system
Although gas chromatography and liquid chromatography have a very strong separation ability, due to the differences in the growth and other conditions of the medicinal materials themselves, that is, the traditional Chinese medicinal medicinal materials are often not strictly controlled from the source, which will cause their "active ingredients" or "controlled ingredients" to be separated. Instability or insufficient reliability, coupled with the fact that standard compounds are not easy to obtain during analysis, making it difficult to achieve identification

Method used

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  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of medicinal materials in Chinese traditional medicine
  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of medicinal materials in Chinese traditional medicine
  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of medicinal materials in Chinese traditional medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: identification and identification of Salvia miltiorrhiza

[0074] (1) Spectrum GX FTIR spectrometer (Perkin Elmer, USA) and DTGS detector were used in the experiment with a resolution of 4 cm-1 and a measurement range of 4000-400 cm-1, and 32 scans were accumulated to obtain spectra. Adopt 50-886 Portable Controller programmable temperature control unit (Love Control Company);

[0075] (2) After the salvia miltiorrhiza sample was crushed, KBr was added, pressed into tablets, and made into a sample, which was placed in a variable temperature pool of the instrument. The temperature was programmed from room temperature to 150°C, and the in-situ real-time interval sampling was carried out. Every time the temperature rose by 10°C, the infrared spectrum was collected, and the series were continuously obtained. Spectrum - variable temperature dynamic spectrum;

[0076] (3) For the infrared spectrum at room temperature (~20°C), perform derivation processing on th...

Embodiment 2

[0098] Embodiment 2: identification and differentiation of Huoxiang

[0099] (1) Spectrum GX FTIR spectrometer (Perkin Elmer, USA) and DTGS detector were used in the experiment, with a resolution of 4 cm-1, a measurement range of 4000-400 cm-1, and 32 scans to accumulate the spectrum. Adopt 50-886 Portable Controller programmable temperature control unit (Love Control Company);

[0100] (2) After the four kinds of Huoxiang samples were pulverized, they were added to KBr pellets to make samples, which were placed in the temperature-changing pool of the instrument. The temperature was programmed from room temperature to 150°C, and the in-situ real-time interval sampling was carried out. The infrared spectrum was collected every 10°C of temperature rise, and was continuously acquired. family spectrum Figure 1 Variable temperature dynamic spectrum;

[0101] (3) For the infrared spectrum at room temperature (~20°C), perform derivation processing on the spectrum to obtain the der...

Embodiment 3

[0132] Example 3: Identification and Differentiation of Star Anise and Mangcao

[0133] (1) Spectrum GX FTIR spectrometer (Perkin Elmer, USA) and DTGS detector were used in the experiment with a resolution of 4 cm-1 and a measurement range of 4000-400 cm-1, and 32 scans were accumulated to obtain spectra. Adopt 50-886 Portable Controller programmable temperature control unit (Love Control Company);

[0134] (2) Star anise and shikigami samples were crushed and added with KBr, pressed into tablets to make samples, placed in the temperature-changing pool of the instrument, the temperature was programmed from room temperature to 150°C, in-situ real-time interval sampling, and infrared spectra were collected every 10°C increase in temperature , to acquire serial spectra continuously Figure 1 Variable temperature dynamic spectrum;

[0135] (3) For the infrared spectrum at room temperature (~20°C), perform derivation processing on the spectrum to obtain the derivative spectrum; ...

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Abstract

This invention relates to a method for verifying unseparately extracted multilever macro-finger makrs with infrared spectrum of Chinese medicine characterizing in cutting, crushing, and screening medicine to add potassium bromide powder into the medicine powder smaller than 200 mesh for table sampling to determine the middle infrared spectrum, diffuse reflection near infrared, diffuse reflection middle infrared spectrum, reflection spectrum and attenuation total reflection spectrum to get and draw the second-order derivative spectrum diagram of related spectrum, to determine the samples two-dimensional celated infrared spection to be compared in level.

Description

technical field [0001] The invention relates to a non-separation extraction spectral analysis identification and identification method of a mixture solution with extremely complex components, in particular to a non-separation extraction infrared spectrum non-separation extraction multi-stage macroscopic fingerprint identification method of Chinese medicinal materials, which belongs to the technical field of traditional Chinese medicine detection. Background technique [0002] The quality control of traditional Chinese medicine is the basis and key to promote traditional Chinese medicine and Chinese medicine. In October 2000, the State Drug Administration of China issued the "Technical Requirements for Fingerprint Research of Traditional Chinese Medicine Injections (Provisional)" to guide and standardize the research on fingerprints of traditional Chinese medicine. The European Community was the first to stipulate fingerprints as quality standards in the form of legislation (...

Claims

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Application Information

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IPC IPC(8): G01N21/3563G01N21/359G01N33/15
Inventor 孙素琴秦竹周群陶家洵
Owner TSINGHUA UNIV
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