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Medicament composition for treating coronary heart disease

A composition and technology for coronary heart disease, applied in the pharmaceutical composition of angina pectoris, in the field of treating coronary heart disease, to achieve the effect of reducing blood viscosity, improving blood rheology, and preventing thrombus formation

Inactive Publication Date: 2004-09-01
谢秀琼 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, after patients take a drug for a long time, it is easy to develop tolerance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] Preparation of Chuanxiong total alkaloids extract:

[0018] Chuanxiong granules are percolated with 30%-70% acidic ethanol (PH3-5.5), the percolation liquid is collected, ethanol is recovered under reduced pressure, and impurity is removed by high-speed centrifugation, and the permeate is ultra-filtered through an inorganic membrane (0.2-0.8 μm). (Molecular weight cut-off 1000~8000) then nanofiltration, collect concentrated solution, spray dry to obtain extract powder: the yield of solid matter is about 10%, wherein the total alkali extract content of Ligusticum chuanxiong is not less than 20%.

[0019] The above-mentioned total alkaloid extract of Chuanxiong is mixed with borneol to obtain the pharmaceutical composition.

[0020] The preparation process of dropping pills:

[0021] Heat the dropping pill matrix in a water bath to dissolve, add the prepared total alkaloid extract of Chuanxiong Rhizoma and borneol, stir well, and prepare according to the conventional pre...

Embodiment 1

[0127] Preparation of Chuanxiong total alkaloids extract:

[0128] Preparation of Chuanxiong total alkaloids extract:

[0129] Chuanxiong medicinal material granule 10kg percolates with 50% acidic ethanol (PH3~5.5), collects percolation liquid, reclaims ethanol under reduced pressure, removes impurity by high-speed centrifugation, crosses inorganic membrane (0.2~0.8 μm), and permeates ultrafiltration ( Molecular weight cut-off 1000~8000) then nanofiltration, collect concentrated solution, spray dry to obtain extract powder 1065g, wherein, after measuring, contain 240g of Rhizoma Chuanxiong total alkali extract.

[0130] The above-mentioned total alkaloid extract of Chuanxiong is mixed with borneol to obtain the pharmaceutical composition.

Embodiment 2

[0132] Preparation of dropping pills:

[0133] Heat and melt polyethylene glycol 6000 320g in a water bath, add 630g of the total alkaloid extract of Ligusticum chuanxiong prepared in Example 1 and 70g of borneol, stir well, and prepare 1000g of dropping pills according to the conventional preparation method of dropping pills.

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PUM

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Abstract

The invention discloses a medicament for treating coronary disease and angina pectoris, the percentage by weight of the ingredients of which are, Ligusticum wallichii total aldali extract 60-95%, borneol 5-40%. The objective of the invention is to provide clinic with a novel, quick-effective, highly performance, low toxic and small dosage medicament, increase the selectivity for clinical medicament, prevent the survivability as the result of long-term administration.

Description

technical field [0001] The invention relates to a pharmaceutical composition, especially a pharmaceutical composition for treating coronary heart disease and angina pectoris. Background technique [0002] Coronary heart disease and angina pectoris are common and frequently-occurring diseases of the cardiovascular system, and they are also one of the refractory diseases. According to statistics, 1 out of every 3 deaths in the world is caused by cardiovascular disease. Now with the improvement of people's living standards, cardiovascular disease, known as the "disease of affluence", is gradually on the rise. Therefore, there is an urgent need for a new type of quick-acting and highly effective specific drug in clinical practice. [0003] At present, the first-aid drugs used to treat coronary heart disease and angina pectoris mainly include Ligustrazine Hydrochloride Injection, Suxiao Jiuxin Pills, Nitroglycerin Buccal Tablets, etc. Although Western med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61P9/10
Inventor 谢秀琼郭东艳罗海燕
Owner 谢秀琼