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Pharmaceutical composition for treaitng coronary heart disease

A composition and technology for coronary heart disease, applied in the pharmaceutical composition of angina pectoris, in the field of treatment of coronary heart disease, to achieve the effects of improving myocardial nutrition blood flow, preventing thrombosis, and reducing blood viscosity

Inactive Publication Date: 2007-04-04
谢秀琼 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, after patients take a drug for a long time, it is easy to develop tolerance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0016] A pharmaceutical composition for treating coronary heart disease and angina pectoris is provided, which consists of the following components

[0017] (weight ratio): 80-99.5% of the total alkaloid extract of Chuanxiong, and 0.5-20% of musk. The preferred composition ratio is (weight ratio) 95-99.5% of total alkali extract of Chuanxiong and 0.5-5% of musk. The above pharmaceutical composition for treating coronary heart disease and angina pectoris, together with pharmaceutically acceptable auxiliary materials, is prepared into an oral preparation. The preferred dosage forms are drop pills or dispersible tablets. The pharmaceutical composition can be used to prepare medicines for treating cardiovascular and cerebrovascular diseases.

[0018] The preparation process of total alkaloids of Chuanxiong Rhizoma:

[0019] Chuanxiong granules are percolated with 30%-70% acidic ethanol (PH3-5.5), the percolation liquid is collected, ethanol is recovered under reduced pressure, ...

Embodiment 1

[0077] Preparation of Chuanxiong total alkaloids extract:

[0078] Chuanxiong medicinal material granule 20kg percolates with 50% acidic ethanol (PH3~5.5), collects percolation liquid, reclaims ethanol under reduced pressure, high-speed centrifugation removes impurity, crosses inorganic membrane (0.2~0.8 μm), ultrafiltration ( Molecular weight cut-off 1000~8000) then nanofiltration, collect concentrated solution, spray dry to obtain extract powder 2100g, wherein, after measuring, contain 480g of Rhizoma Chuanxiong total alkali extract.

Embodiment 2

[0080] Preparation of dropping pills:

[0081] Heat and dissolve polyethylene glycol 6000 315g in a water bath, add 698g of total alkaloid extract of Ligusticum chuanxiong prepared in Example 1 and 12g of musk, stir well, and prepare 1000g of dropping pills according to the conventional preparation method of dropping pills.

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PUM

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Abstract

The invention discloses a medicinal composition for treating coronary disease and angina pectoris, the percentage by weight of the ingredients of which are, Ligusticum wallichii total alkali 70-99.9%, musk 70-99.9%. The objective of the invention is to provide a novel, quick-effective, highly performance, low toxic and low dosage medicament, increasing the selection of clinical medicine, and preventing the survivability resulted from long-term administration.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating coronary heart disease and angina pectoris. Background technique [0002] Coronary heart disease and angina pectoris are common and frequently-occurring diseases of the cardiovascular system, and they are also one of the refractory diseases. According to statistics, 1 out of every 3 deaths in the world is caused by cardiovascular disease. Now with the improvement of people's living standards, cardiovascular disease, known as the "disease of affluence", is gradually on the rise. Therefore, there is an urgent need for a new type of quick-acting and highly effective specific drug in clinical practice. [0003] At present, the first-aid drugs used to treat coronary heart disease and angina pectoris mainly include Ligustrazine Hydrochloride Injection, Suxiao Jiuxin Pills, Nitroglycerin Buccal Tablets, etc. Although Western medicines are effective and quick, they ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/236A61K35/55A61K9/20A61P9/10
Inventor 谢秀琼郭东艳罗海燕
Owner 谢秀琼