CD8 alpha + lymphoid dendritic cell differentiated from human hematopoietic stem cell and a method for differentiation

A technology of dendritic cells and artificial blood, applied in biochemical equipment and methods, blood/immune system cells, animal cells, etc.
CN1543502AInactive Publication Date: 2004-11-03金炫寿 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
金炫寿
Publication Date
2004-11-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Lymphoid dendritic cells with immunophenotype CD8alpha+ can be produced by a method which comprises culturing human hematopoietic stem cells in a medium containing GM-CSF, followed by culturing in a medium containing IFN-Upsilon, the lymphoid dendritic cells being useful in various immunotherapies.
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Description

technical field

[0001] The present invention relates to lymphoid dendritic cells differentiated from human hematopoietic stem cells, a method for differentiating lymphoid dendritic cells from human hematopoietic stem cells, and a pharmaceutical composition containing lymphoid dendritic cells as an active ingredient for immunotherapy. Background technique

[0002] Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that coordinate various immune responses against specific antigens and simultaneously suppress autoimmune responses by eliminating potentially autoreactive T cells.

[0003] Murine DCs can be subdivided into at least two distinct subtypes, myeloid DS and lymphoid DCs, based on their anatomical localization, transplantation experiments, and cell surface phenotype. have CD11c + , MHCII + , CD4 + , CD8α - DCs with a cell surface phenotype known as CD8α - Myeloid DC, which can be derived from bone marrow precursor cells, has CD11c + , MHCII + , CD4 ...

Claims

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