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Secnidazole injection and its prepn process

A technology of secnidazole and injection, applied in the direction of diseases, antibacterial drugs, anti-infective drugs, etc., can solve the problems of secnidazole injection reports and other issues

Inactive Publication Date: 2004-11-24
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After experiments, it was found that the antibacterial effect of its secnidazole injection is more obvious than that of oral dosage forms; at present, there is no secnidazole injection approved for marketing at home and abroad, and there is no report about secnidazole injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment one 0.2% secnidazole sodium chloride injection

[0008] prescription:

[0009] Secnidazole 20g

[0010] Sodium Chloride 90g

[0011] Add water for injection to 10000ml

[0012] Preparation process: take the secnidazole and sodium chloride of the recipe, add water for injection to about 90% of the total amount, heat to boil, stir to dissolve, add 0.02% (g / ml) medicinal activated carbon, boil for 10 minutes, Cool to 50~60℃, filter and decarbonize, make up the water to the full amount, after the content is qualified, filter through 0.45μm microporous membrane, potting, sterilize at 115℃ for 30min, light inspection, and packaging.

Embodiment 2

[0013] Embodiment two 0.1% secnidazole sodium chloride injection

[0014] prescription:

[0015] Secnidazole 10g

[0016] Sodium Chloride 90g

[0017] Add water for injection to 10000ml

[0018] Preparation process: take the secnidazole and sodium chloride of the recipe, add water for injection to about 90% of the total amount, heat to boil, stir to dissolve, add 0.02% (g / ml) medicinal activated carbon, boil for 10 minutes, Cool to 50~60℃, filter and decarbonize, make up the water to the full amount, after the content is qualified, filter through 0.45μm microporous membrane, potting, sterilize at 115℃ for 30min, light inspection, and packaging.

Embodiment 3

[0019] Embodiment three 0.5% secnidazole sodium chloride injection

[0020] prescription:

[0021] Secnidazole 50g

[0022] Sodium Chloride 90g

[0023] Add water for injection to 10000ml

[0024] Preparation process: take the secnidazole and sodium chloride of the recipe, add water for injection to about 90% of the total amount, heat to boil, stir to dissolve, add 0.02% (g / ml) medicinal activated carbon, boil for 10 minutes, Cool to 50~60℃, filter and decarbonize, make up the water to the full amount, after the content is qualified, filter through 0.45μm microporous membrane, potting, sterilize at 115℃ for 30min, light inspection, and packaging.

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PUM

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Abstract

The present invention is the recipe and preparation process of Secnidazole injection as anaerobe resisting medicine. The Secnidazole injection is prepared with Secnidazole as main medicinal component and adding isotoic regulator and other supplementary material. The preparation process includes water dissolution, filtering and packing.

Description

technical field [0001] The invention relates to a prescription of an anti-anaerobic bacteria drug secnidazole injection and a preparation process thereof. Background technique [0002] Secnidazole is a drug similar in chemical structure to 5-nitroimidazole antibiotics such as metronidazole and tinidazole. This kind of drug has a strong killing effect on anaerobic bacteria, whether it is Gram-negative or Gram-positive; it has special effects on amoeba, giardia, trichomoniasis and bacterial vaginitis. In recent years, with the widespread use of metronidazole and tinidazole at home and abroad, the resistance to these two drugs is increasing, and in some countries it is even as high as 60%, while secnidazole can overcome the above two drugs. The resulting problem of drug resistance. Through experiments, it is found that the antibacterial effect of its secnidazole injection is more obvious than that of the oral dosage form; at present, there is no secnidazo...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61P15/02A61P31/04A61P33/02
Inventor 马越峰
Owner 浙江南洋药业有限公司
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