Sinlmenine hydrochloride plaster and its preparation method
A technology of sinomenine hydrochloride and poultice, applied in the field of medicine, can solve the problems of short biological half-life and easy decomposition, and achieve the effects of enhancing analgesia, improving compliance, and reducing the fluctuation of blood drug concentration
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[0010] Example 1:
[0011] Sinomenine Hydrochloride 2g
[0012] Glycerin 5g
[0013] Polyacrylic acid (Carbopol Ultrez 10) 0.4g
[0014] Sodium polyacrylate (Carborit 7S) 0.8g
[0015] Sodium polyacrylate (Carborit K39) 0.8g
[0016] Tartaric acid 0.06g
[0017] Aluminum hydroxide 0.04g
[0018] Deionized water 10g
[0019] Penetration enhancer 0.5g
[0020] Total 19.6g
[0021] Preparation:
[0022] 1. Disperse the polymer in glycerin to obtain phase A;
[0023] 2. Mix aluminum hydroxide and tartaric acid in a small amount of deionized water to obtain phase B;
[0024] 3. Add the penetration enhancer and the drug into sufficient deionized water to obtain phase C;
[0025] 4. Mix phase A and phase B, disperse in phase C under stirring, and evenly coat it on the non-woven fabric, and cover it with a release layer to get it.
[0026] The above dosage can prepare 5 patches of 5cm×5cm cataplasma, each patch contains 400mg of sinomenine hydrochloride and has a water content of 51%.
Example Embodiment
[0027] Example 2:
[0028] Sinomenine Hydrochloride 2g
[0029] Glycerin 5g
[0030] Polyacrylic acid (Carbopol Ultrez 10) 0.8g
[0031] Sodium polyacrylate (Carborit 7S) 1.0g
[0032] Sodium polyacrylate (Carborit K39) 0.2g
[0033] Tartaric acid 0.05g
[0034] Aluminum hydroxide 0.03g
[0035] Deionized water 10g
[0036] Penetration enhancer 0.5g
[0037] Total 19.58g
[0038] The preparation method is the same as the above example.
[0039] The above dosage can prepare 5 patches of 5cm×5cm cataplasma, each patch contains 400mg of sinomenine hydrochloride and has a water content of 51%.
Example Embodiment
[0040] Example 3:
[0041] Sinomenine Hydrochloride 2g
[0042] Glycerin 5g
[0043] Polyacrylic acid (Carbopol Ultrez 10) 1.2g
[0044] Sodium polyacrylate (Carborit 7S) 0.6g
[0045] Sodium polyacrylate (Carborit K39) 0.2g
[0046] Kaolin 1g
[0047] Tartaric acid 0.06g
[0048] Aluminum hydroxide 0.04g
[0049] Deionized water 9g
[0050] Penetration enhancer 0.5g
[0051] Total 19.6g
[0052] The preparation method is the same as the above example.
[0053] The above dosage can prepare 5 patches of 5cm×5cm cataplasma, each patch contains 400mg of sinomenine hydrochloride and the water content is 45.9%.
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