Application of ginsenoside monomer Rb#[1] in the preparation process of medicine for treating myocardial ischemia and heart failure
A ginsenoside, myocardial ischemia technology, applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as damage to the human body, toxic side effects, etc.
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example 1
[0006] Example 1 Rb 1 Improve endothelin-1 induced heart failure in guinea pigs in vivo
[0007] Establish several experimental dosage groups, each group of 10 adult healthy guinea pigs (300-350g) was anesthetized, opened the chest, artificially respired, inserted a polyethylene catheter (inner diameter 1.5mm) into the ventricle, and recorded the electrocardiogram synchronously with a polyconductor recorder ( ECG), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), indoor maximum rate of rise and fall (±dp / dt), heart rate (HR) and hemodynamic indicators (AF, SV, CBF). Firstly, the above normal indexes were recorded, and after 10 minutes of stabilization, endothelin-1 (37.5 μg / kg) was injected intravenously to make a heart failure model, and compared with the normal above indexes. The state of heart failure lasted for 5 minutes before injecting Rb from the vein 1 285μg / kg, the results showed that Rb 1 Significantly improved heart fai...
example 2
[0018] Example 2 Rb 1 Improvement of Endothelin-1-induced Heart Failure in Guinea Pigs
[0019] Several experimental groups were set up, with 8 adult healthy guinea pigs (300-350 g) in each group. The animals were sacrificed by disconnecting the marrow, and the heart was quickly taken out, and arterial cannulation was performed immediately for reverse perfusion. Using the Langenderff isolated perfusion method, the left ventricle was intubated. Record the left ventricular pressure, place electrodes at the apex of the heart to guide the electrocardiogram, and perform reverse perfusion for 10 minutes. 2 +5%CO 2 The pH of the mixed gas is 7.4-7.5, and the isolated heart works under the conditions of a preload of 15 cm water mark and an afterload of 70 cm water mark. Its indicators are the same as in Example 1. After stabilization, record various normal indicators as a contrast. After 10 minutes, endothelin-1 (100pmol / L) is poured into heart failure, and the above indicators are ...
example 3
[0029] Example 3 Rb 1 Improve endothelin-1 induced myocardial ischemia in rats
[0030] A number of experimental dose groups were set up, with 10 rats (400-450 g) in each group. After anesthesia, the electrocardiogram index was recorded with the second lead of the electrocardiogram. The normal index was stable for 10 minutes, and the ST segment was moved down as a reference.
[0031] Inject ET-1 (10 μg / kg) into the tail vein, take ST-segment downshift of 0.2mv as the obvious indicator of myocardial ischemia, and inject Rb after 10 minutes of stable myocardial ischemia 1 (40mg / kg), the results showed that Rb 1 Significantly improved the phenomenon of myocardial ischemia caused by endothelin-1. The results are listed in Table-3.
[0032] Table-3: Rb 1 Improve endothelin-1 induced myocardial ischemia in rats
[0033] HR ST displacement
[0034] R(mv) QRS(ms) T(mv) QT(ms)
[0035] (times) (mv)
[0036]...
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