Trimetazidine new use in prevention and treatment of sepsis-caused cardiac insufficiency
A technology of cardiac insufficiency and trimetazidine, which is applied in trimetazidine, a new application field in the prevention and treatment of sepsis and cardiac insufficiency
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Embodiment 1
[0021] The preventive effect of embodiment 1 oral trimetazidine to sepsis heart insufficiency
[0022] C57 mice were randomly divided into 4 groups: 1) control group (gastric administration of normal saline), 2) trimetazidine control group (TMZ, 20mg / kg, oral administration, three times a day), 3) lipopolysaccharide group ( LPS, 15mg / kg, intraperitoneal injection), 4) trimetazidine prevention group (TMZ+LPS, TMZ20mg / kg, oral gavage, three times a day, give LPS15mg / kg, intraperitoneal injection after 3 days), each group of 8 .
[0023] After C57 mice were fed in SPF environment for one week, they were given prophylactic oral administration of trimetazidine, followed by LPS 3 days later. Six hours after intraperitoneal injection of LPS, cardiac function tests were performed using small animal high-frequency echocardiography and Millar cardiac catheterization system. Then the animals were sacrificed, and the hearts were fixed in formalin, embedded and sectioned, and the heart m...
Embodiment 2
[0026] Therapeutic effect of embodiment 2 oral trimetazidine to sepsis heart insufficiency
[0027] C57 mice were randomly divided into 4 groups: 1) control group (gastric administration of normal saline), 2) trimetazidine control group (TMZ, 20mg / kg, oral administration, three times a day), 3) lipopolysaccharide group ( LPS, 15mg / kg, intraperitoneal injection), 4) trimetazidine treatment group (LPS+TMZ, LPS15mg / kg, 6 hours after intraperitoneal injection, start to give TMZ20mg / kg, oral gavage, three times a day, last 24 hours ), 8 in each group.
[0028] After C57 mice were bred in SPF environment for one week, they were given intraperitoneal injection of LPS, and 6 hours later, trimetazidine 20mg / kg was given orally orally, three times a day for 24 hours, and the tail vein of small animals was used every 6 hours during this period. The blood pressure of the mice was monitored by a blood pressure measuring instrument. At the end point, small animal high-frequency echocardio...
Embodiment 3
[0034] Example 3 Preventive and therapeutic effects of intravenous injection of trimetazidine to sepsis with cardiac insufficiency
[0035] In the preventive effect, C57 mice were randomly divided into 4 groups: 1) control group (normal saline tail vein injection), 2) trimetazidine control group (TMZ, 20mg / kg, tail vein injection, twice a day), 3) lipopolysaccharide group (LPS, 15mg / kg, intraperitoneal injection), 4) trimetazidine prevention group (TMZ+LPS, TMZ20mg / kg, tail vein injection, twice a day, 3 days later, LPS15mg / kg, intraperitoneal injection) injection), 8 rats in each group.
[0036] After C57 mice were fed in SPF environment for one week, they were given prophylactic tail vein injection of trimetazidine, and LPS was given 3 days later. Six hours after intraperitoneal injection of LPS, cardiac function tests were performed using small animal high-frequency echocardiography and Millar cardiac catheterization system.
[0037] In the therapeutic effect, C57 mice we...
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