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Method for guaranteeing its component content stability in Chinese medicine extract blending optimization

An extract and content technology, applied in the field of improving the quality and stability of traditional Chinese medicine extracts, can solve the problems of inconsistent content of active ingredients of medicinal materials, hindering the development of traditional Chinese medicine industry, unstable efficacy of final products of traditional Chinese medicine, etc. The effect of adaptability, high flexibility

Inactive Publication Date: 2005-03-02
ZHEJIANG UNIV
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Problems solved by technology

In the production process of traditional Chinese medicine, the content of active ingredients in different batches of medicinal materials is often inconsistent, which may eventually lead to unstable efficacy of the final product of traditional Chinese medicine, hindering the further development of the Chinese medicine industry

Method used

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  • Method for guaranteeing its component content stability in Chinese medicine extract blending optimization
  • Method for guaranteeing its component content stability in Chinese medicine extract blending optimization
  • Method for guaranteeing its component content stability in Chinese medicine extract blending optimization

Examples

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Embodiment

[0052] 1. Select a batch of high-quality Fructus Aurantii medicinal materials, extract with ethanol solution to obtain the standard extract of Fructus Aurantii, and measure the standard chromatographic fingerprint and naringin content by HPLC method; and according to the provisions of the Chinese Pharmacopoeia, select naringin as the index component.

[0053] 2. Select 5 batches of Fructus aurantii medicinal materials from different origins, and extract with ethanol solution to obtain Fructus aurantii extract. The chromatographic fingerprints and naringin content of these five batches of Fructus Fructus Fructus extracts were determined by HPLC.

[0054]3. Determine that the similarity threshold is 0.95, and the relative concentration deviation threshold is 0.05. Input the chromatographic fingerprints and naringin content, standard chromatographic fingerprints and naringin content of each batch of Citrus aurantium extract into the blending model, and calculate The optimal blend...

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Abstract

The method of blending Chinese medicine extract to ensure the component content stability includes the following steps: determining the standard extract and measuring its chromatographic fingerprint and effective component content; extracting the medicine material of different batches separately to obtain the extracts and measuring the chromatographic fingerprint and effective component content of the batches; inputting the chromatographic fingerprint and effective component content of the batches and the chromatographic fingerprint and effective component content of the standard extract into the blending mold to obtain optimized mixing ratio; and mixing the extracts of the different batches based on the calculated values to obtain the extract with the same quality as the standard extract. The method of the present invention can ensure the stable Chinese medicine product quality.

Description

technical field [0001] The invention relates to a method for improving the quality stability of Chinese medicine extracts, in particular to a method for blending Chinese medicine extracts for improving the quality stability of Chinese medicine extracts. Background technique [0002] The composition of traditional Chinese medicine is very complex. A single traditional Chinese medicine often contains dozens to hundreds of different compounds, and its curative effect is the result of the synergistic effect of multiple active ingredients. Most of the active ingredients of traditional Chinese medicine are secondary metabolites of medicinal plants. Due to the influence of factors such as the climate and geographical characteristics of the planting and cultivation area, and the collection time, the concentration distribution of the chemical ingredients has varying degrees of volatility. In the production process of traditional Chinese medicine, the content of active ingredients in ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/00G01N33/15
Inventor 瞿海斌程翼宇欧丹林刘雪松
Owner ZHEJIANG UNIV
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