Microencapsulation method of Chinese traditional medicine

A technology of traditional Chinese medicine and pharmacopoeia, which is applied in the field of traditional Chinese medicine package drug loading, can solve the problems of high resistance of medicine preparations, unstable drug content, and harsh production environment, so as to improve bioavailability, improve drug fluidity and compressibility, overcome sublimation effect

Inactive Publication Date: 2005-03-16
TIANJIN UNIV
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  • Abstract
  • Description
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Problems solved by technology

The microencapsulation method of traditional Chinese medicine solves the problem of unstable drug content and harsh production environment caused by the volatilization and sublimat

Method used

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  • Microencapsulation method of Chinese traditional medicine
  • Microencapsulation method of Chinese traditional medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 10g of borneol, dissolve it in 100ml of ethanol, and add 3g of polyvinylpyrrolidone. Microcrystalline cellulose 1g, ultrasonically mixed, added dropwise to 500ml aqueous solution containing 0.5g each of gelatin and gum arabic. When adding dropwise, stir the water phase to make it fully mixed, ultrasonically disperse for 30 minutes, adjust the pH value to 4, react for 1 hour, add a cross-linking agent, that is, a total of 5ml of 20% formaldehyde solution and 5% glutaraldehyde solution, Adjust the pH value to 8, cross-link and solidify for 2 hours to obtain borneol microcapsules. The filtered product was washed with water, and post-treated with 20 ml of 5% citric acid solution for 10 hours to obtain borneol microcapsules with an average particle size of 50-60 um.

[0023] The efficacy of encapsulating drug-loaded microcapsules is as follows: figure 1 with figure 2 shown. figure 1 It is a comparison chart of the sublimation amount and time relation curve of borne...

Embodiment 2-4

[0025] Take 10 g of sage oil (or cane oil, or cocklebur seed oil) and 1 g of ethyl cellulose, dissolve them in 50 ml of ethyl acetate, and prepare an oil phase. 1 g of sodium lauryl sulfate was dissolved in 100 ml of water, and 1 ml of ethyl acetate was added to prepare an aqueous solution saturated with ethyl acetate, which was used as the water phase. Under the condition of stirring the water phase, drop the oil phase into the water phase at a constant speed, cross-link and solidify for 2 hours, then add 500ml of water, remove the solvent, and then the oily oil (or Atractylodes atractylodes oil, or Cocklebur seed oil) can be formed. Microcapsules. Then filter and dry to obtain microcapsules. The average particle size of microcapsules is 50-60um. The encapsulation rate is 99%.

Embodiment 5

[0027] Take 10 g of Chuanxiong oil and 1 g of polyacrylic acid resin, and dissolve them in 50 ml of ethyl acetate to prepare an oil phase. Take 100ml of water, add 2g of polyethylene glycol, and sonicate for 30 minutes to prepare an aqueous phase. Under the condition of stirring the water phase, drop the organic phase into the water phase at a uniform speed, solidify for 3 hours, remove the solvent, filter and dry to obtain the drug-loaded microcapsules of Rhizoma Chuanxiong. Others are with embodiment 2-4. The average particle size is 50-60um. The encapsulation rate is 90%.

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Abstract

The invention relates to a coated medicine-carrying process for volatile medicament or oil form traditional Chinese medicine with mucosity such as borneol, which consists of dissolving the medicinal components and capsule material in organic solvent, stirring and charging into the aqueous phase of surface active agent, then performing cross-linking, aging, filtering and drying, thus obtaining coated medicine-carrying microcapsule or microsphere.

Description

technical field [0001] The invention belongs to the traditional Chinese medicine package medicine loading technology. It involves dispersion and encapsulation of Chinese medicine volatile oil, volatile medicines, extracts and oils obtained by various extraction methods, and drug-carrying technology; it provides a pharmaceutical method for Chinese medicine drug-carrying with large drug-loading capacity and stable drug-carrying performance. Background technique [0002] The composition of traditional Chinese medicine is complex, and Chinese patent medicine is composed of many kinds of traditional Chinese medicine. Volatile oil, volatile borneol, peppermint, etc. are commonly used traditional Chinese medicines. In the current production process of preparations, at present, they are directly pulverized or sprayed into group medicines, and then prepared into corresponding preparations. Borneol, peppermint are used as medicine and there are two major technical problems in the cu...

Claims

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Application Information

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IPC IPC(8): A61K9/50
Inventor 张韻慧李宁肖莉许建辰
Owner TIANJIN UNIV
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