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Device and method for manufacturing bead array, and method for detecting target substance

A manufacturing method and technology for manufacturing devices, which can be used in biological testing, measuring devices, chemical instruments and methods, etc., and can solve problems such as difficulties

Inactive Publication Date: 2005-06-15
SEIKO EPSON CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although a single type or multiple types of bio-related substances composed of arbitrary mixing ratios can be selected in good time for a reaction area such as a well of a microtiter plate, it is difficult to correctly arrange a small amount of particles in the reaction area

Method used

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  • Device and method for manufacturing bead array, and method for detecting target substance
  • Device and method for manufacturing bead array, and method for detecting target substance
  • Device and method for manufacturing bead array, and method for detecting target substance

Examples

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Embodiment 1

[0040] figure 1 It is a perspective view showing the outline of the microarray manufacturing apparatus used in this example. The microarray manufacturing apparatus 10 is equipped with a chuck support (sledge) 12 that can reciprocate on the X-axis on the base 11 and a table 13 that can reciprocate in the Y-axis direction perpendicular to the X-axis. A suction unit 14 for filling the ejection liquid, and a carriage and table driving unit 15 are disposed at the starting point position of the holder 12 (a storage position in an area other than the movable area of ​​the table 13 ). The driving unit 15 moves the chuck holder 12 and the stage 13 by a numerical control method, etc., using a timing pulley mechanism or a ball screw mechanism, so as to determine the supply position of the ejection liquid to the microarray substrate 12 . A discharge head (not shown) is mounted on the chuck holder.

[0041] In this embodiment, a discharge head using an electrostatic driver is used. fig...

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Abstract

The invention provides a particle array manufacturing device and a particle array manufacturing method. The particle array manufacturing apparatus includes a mechanism for storing a liquid containing particles of a bio-related substance immobilized on the surface, and a mechanism for ejecting the liquid containing the particles to an arbitrary position on a solid-phase substrate. According to the particle array manufacturing apparatus of the present invention, the particles can be supplied to arbitrary reaction regions on the solid-phase substrate with better precision.

Description

technical field [0001] The present invention relates to an apparatus for producing a microarray containing particles having biologically relevant substances immobilized on its surface, a method for producing the same, and a method for detecting a target substance. Background technique [0002] Now, the technology for analyzing genes and proteins has advanced dramatically, and the mechanisms associated with specific diseases or cancers are also being elucidated. Based on this knowledge, microarrays can be used for rapid disease diagnosis, physical examination, and the like. Microarrays are divided into DNA microarrays and protein microarrays. [0003] Since DNA microarrays arrange many nucleic acid probe spots with known sequences on the surface of the solid phase substrate, the interaction (hybridization) of complementary nucleic acid strands is used to capture the target nucleic acid, and the target nucleic acid is captured by surface plasmon resonance (SPR) or fluorescent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53B01J19/00B01L3/00B01L3/02C12N11/00C12N15/09C12Q1/68C40B40/06C40B40/10C40B60/14G01N35/10G01N37/00
CPCB01J19/0046B01J2219/00317B01J2219/00378B01J2219/00466B01J2219/005B01J2219/00545B01J2219/00554B01J2219/00563B01J2219/00574B01J2219/00576B01J2219/00596B01J2219/00722B01J2219/00725B01L3/0241B01L3/5085C40B40/06C40B40/10C40B60/14Y10T436/2575C12Q1/6834C12Q2563/149
Inventor 高城富美男
Owner SEIKO EPSON CORP
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