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Susceptibility gene closely related to schizophrenia

A schizophrenia and susceptibility gene technology, applied in genetic engineering, plant genetic improvement, and the determination/inspection of microorganisms, can solve the problem of not finding schizophrenia susceptibility genes, and achieve considerable social and economic benefits.

Inactive Publication Date: 2005-06-22
JILIN UNIV
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Problems solved by technology

But so far no specific susceptibility genes related to schizophrenia have been found in this chromosome region

Method used

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  • Susceptibility gene closely related to schizophrenia
  • Susceptibility gene closely related to schizophrenia
  • Susceptibility gene closely related to schizophrenia

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Effect test

Embodiment Construction

[0057] The genotype analysis of single nucleotide polymorphism rs3782929 was carried out by extracting the subjects' genomic DNA, and the individuals whose rs3782929 base was G were the susceptible population of schizophrenia.

[0058] 1. Genomic DNA Extraction

[0059] 5ml of anticoagulated blood was drawn from the peripheral vein of the subjects, and genomic DNA was extracted with Singpu Liquid Micro DNA Extraction Kit (Ningbo). The steps are as follows: ①Take 100 μl of blood sample, add it to a 1.5ml centrifuge tube, then add 100 μl of 1×TE buffer, and shake well; ②While shaking, add 200 μl of B1 reagent and mix well; ③Add 200 μl of ④ Move the mixed solution into the spinning spin column and centrifuge (14000rpm, minute); ⑤ Add 400μl of B3 reagent to the spinning spin column and centrifuge (14000rpm, 1 minute); ⑥Repeat the above steps; ⑦ Centrifuge the empty column (14000rpm, 2 minutes), transfer the spinning spin column into a clean 1.5ml centrifuge tube, add 100μl of B4 ...

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Abstract

The invention provides a susceptibility gene closely related to schizophrenia, i.e. Karyopherin alpha 3 (KPNA3) gene containing two mononucleotide polymorphism sequence length of 93596bp, because accident mutation occurs on the mononucleotide polymorphism rs3782929 base C of the gene into G, it is related to the susceptibility of schizophrenia. The individuals whose rs3782929 base is G are susceptible population of schizophrenia, while the individuals whose rs3782929 base is an are not susceptible to schizophrenia.

Description

technical field [0001] The present invention relates to a susceptibility gene KPNA3 significantly associated with schizophrenia. Background technique [0002] Schizophrenia is one of the most serious mental illnesses. In my country, the lifetime prevalence rate of schizophrenia is as high as 0.7%. Such a large group of patients not only brings a heavy economic burden to families and society, but also seriously threatens social security and stability. Therefore, to determine the etiology of schizophrenia and to establish effective prevention methods has become an urgent problem to be solved in the medical field and even the whole society. Schizophrenia is closely related to genetic factors and is classified as a polygenic genetic disease. A systematic scan of the human genome found that, except chromosomes 19, 21 and Y, all other chromosomes may contain schizophrenia susceptibility genes. Locating the susceptibility genes of schizophrenia using linkage and association met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C12Q1/68
Inventor 尉军于雅琴张海英鞠桂芝刘树铮沈岩张萱史杰萍谢林许琪胡颖
Owner JILIN UNIV
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