Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Freeze dried injection of seeding of autumnal sowthistle-leaf ixeris and preparation method thereof

A technology of freeze-dried powder injection and Kudiezi, which is applied in the field of Kudiezi freeze-dried powder injection and its preparation, and can solve the problems of undiscovered Kudiezi freeze-dried powder injection report and other issues

Inactive Publication Date: 2005-07-06
张平
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] No other reports about Kudiezi freeze-dried powder injection were found in the data retrieval

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] (1) The prescription of raw material medicine is: Kudiezi 1000g.

[0087] (2) Take Kudiezi medicinal material, crush it through a 40-mesh sieve, add 7 times the amount of 70% ethanol, and extract it twice with 20KHz frequency ultrasound, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure. Get bitter dish extract.

[0088] (3) Add an appropriate amount of distilled water to the Kudiezi extract to make the liquid contain 1g of crude drug / ml, stir well, place it in the refrigerator overnight, centrifuge at high speed, take the supernatant for ultrafiltration, absorb the ultrafiltrate on a polyamide resin column, and wash with water until The effluent was colorless, and then eluted with 4 times the column volume of 70% ethanol. The 70% ethanol eluate was combined, and the ethanol was recovered under reduced pressure and concentrated to obtain 6.0 g of Kudiezi extract.

[0089] ...

Embodiment 2

[0092] (1) The prescription of raw material medicine is: Kudiezi 1000g.

[0093] (2) Take Kudiezi medicinal material, crush it through a 30-mesh sieve, add 8 times the amount of 70% ethanol, and extract it twice with 20KHz frequency ultrasound, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure. Get bitter dish extract.

[0094] (3) Add an appropriate amount of distilled water to the Kudiezi extract to make the liquid contain 1g of crude drug / ml, stir well, place it in the refrigerator overnight, centrifuge at high speed, take the supernatant for ultrafiltration, absorb the ultrafiltrate on a polyamide resin column, and wash with water until The effluent was colorless, and then eluted with 5 times column volume of 75% ethanol. The 75% ethanol eluate was combined, and the ethanol was recovered under reduced pressure and concentrated to obtain 6.5 g of Kudiezi extract.

[0095] (4) ...

Embodiment 3

[0098] (1) The prescription of raw material medicine is: Kudiezi 800g.

[0099] (2) Take Kudiezi medicinal material, crush it through a 50-mesh sieve, add 6 times the amount of 70% ethanol, and extract it twice with 20KHz frequency ultrasound, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure. Get bitter dish extract.

[0100] (3) Add an appropriate amount of distilled water to the Kudiezi extract to make the liquid contain 1g of crude drug / ml, stir well, place it in the refrigerator overnight, centrifuge at high speed, take the supernatant for ultrafiltration, absorb the ultrafiltrate on a polyamide resin column, and wash with water until The effluent was colorless, and then eluted with 3 times the column volume of 60% ethanol, combined the ethanol eluent, recovered the ethanol under reduced pressure and concentrated to obtain 5.0 g of Kudiezi extract.

[0101] (4) Preparation p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a freeze dried injection of seeding of autumnal sowthistle-leaf ixeris and preparation method, wherein the injection is prepared from seeding of autumnal sowthistle-leaf ixeris extract and medicinal adjuvant, the preparation consists of ultrasonic extraction, high speed centrifuging and ultrafiltrating the extract, disintegrating and purifying with polyamide resin columns.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Kudiezi freeze-dried powder injection and a preparation method thereof. Background technique [0002] Kudiezi, also known as Kudian Kusao, is the dry whole herb of the plant of Compositae. Bitter, pungent and flat in nature, it has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. Its main components are flavonoid glycosides and adenosine. Modern studies have proved that the drug has the effects of increasing coronary blood flow and improving myocardial circulation in the circulatory system, and can significantly inhibit platelet aggregation and significantly increase the activity of fibrinolytic enzymes in the blood system. The marketed preparation is Kudiezi Injection (WS-10354(ZD-0354)-2002). Kudiezi Injection has the effects of promoting blood circulation, relieving pain, clearing away heat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P9/10
Inventor 张平
Owner 张平
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com