Apparatus and method for delivery of bacteria to the vaginal tract

A bacterial and vaginal technology, applied in the directions of bacterial medical raw materials, drug delivery, sheet delivery, etc., can solve the concerns of potential users and the difficulty of obtaining lactobacilli.

Inactive Publication Date: 2005-07-27
KIMBERLY-CLARK WORLDWIDE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The success of this treatment is dependent on the colonization of Lactobacilli, which can be difficult to obtain due to the unfavorable envi...

Method used

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  • Apparatus and method for delivery of bacteria to the vaginal tract
  • Apparatus and method for delivery of bacteria to the vaginal tract
  • Apparatus and method for delivery of bacteria to the vaginal tract

Examples

Experimental program
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Embodiment

[0040] In order to verify the use of the present invention in the treatment of vaginal infections, the following experiments were carried out. Lyophilized Lactobacillus acidophilus (ATCC4356) was grown in ATCC recommended growth medium containing 100 g skim milk, 100 mL filtered tomato juice, 5 g yeast extract, and distilled water to make a total of 1 L . After 24 hours, 5 microliters of growth medium were diluted to 100 microliters and plated onto media of the same composition + 1.5 wt% agar. After 24 hours, pick 1 colony and grow it in 6 ml of growth medium for 36 hours to a concentration of 1.37 × 10 8 bacteria / ml.

[0041] A concentrated alginate solution was prepared, which consisted of 3% by weight sodium alginate (named Fluka 71238, purchased from Fluka BioChemika, Switzerland) and distilled water. A SPECTRA / POR(R) dialysis membrane (3,500 molecular weight cutoff, 11.5 mm diameter) available from Spectrum Laboratories, California, USA was hydrated with sterile water....

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Abstract

The present invention relates to a treatment for vaginal infections that does not promote colonization of artificially introduced bacteria such as Lactobacillus. Beneficial bacteria are contained within an outer cover of a vaginal insert that does not allow the bacteria to contact the vaginal tissue. The outer cover allows passage of metabolic byproducts produced by the beneficial bacteria into the vaginal tract creating an environment hostile to pathogenic microorganisms. The vaginal insert is placed in the vaginal tract by the user either by hand or by an instrument such as a tampon applicator. When the treatment time elapses the vaginal insert is removed.

Description

technical field [0001] The present invention relates to a vaginal insert for delivering beneficial bacteria and metabolic by-products of beneficial bacteria into the vagina. Beneficial bacteria are contained within the vaginal insert, and only the by-products of this bacteria are able to escape from the insert, allowing the vagina to receive the benefits of these bacteria without colonization of the vagina by artificially introduced bacteria. Background technique [0002] The human genitourinary system contains naturally occurring non-pathogenic bacteria. A normal vagina contains non-pathogenic bacteria and a small amount of yeast. However, in a normal, healthy vagina, the normal balance of microbial flora is often disrupted by organisms from the gastrointestinal system, the use of antibiotics, various health problems, and even too much sex. [0003] Bacterial vaginosis and yeast infection are two possible results of an upset balance of bacteria in the vagina, with symptom...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/16A61K9/22A61K35/74A61K35/745A61K35/747A61P15/02
CPCA61K35/745A61K35/747A61K9/0036A61K9/1652A61P15/02A61K9/70A61M31/00
Inventor R·G·佩恩金在护R·J·林
Owner KIMBERLY-CLARK WORLDWIDE INC
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