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New recipe and prepn process of blood fat reducing medicine

A preparation and blood lipid technology, which is applied in the field of new formulations and preparations for reducing blood lipids, can solve the problems of decelerating cholesterol synthesis, single function, and poor effect on cholesterol levels, and achieve the effect of eliminating compensatory absorption increase

Inactive Publication Date: 2005-09-28
李安国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: because red yeast rice or red yeast rice preparations contain lovastatin, they have toxic and side effects on human kidneys, liver and muscles, and can only slow down the synthesis of cholesterol in the liver and cannot inhibit cholesterol in the intestinal tract. The absorption and function of the drug are single, and the effect of lowering the serum cholesterol level of the human body is not good, and increasing the dosage will further enhance the toxic and side effects of lovastatin contained in it.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0045] Example 1: Red Yeast Extract and Phytosterol Co-dissolution Mixing:

[0046] The red yeast rice dry powder is not extracted with 75-100% ethanol, the extract is volatilized, dried and weighed, and then dissolved in an appropriate amount of absolute ethanol, and the amount of monacolin K is determined by high performance liquid chromatography (HPLC), and Calculate the monacolin K weight percent in the extract. Add phytosterols to the absolute ethanol solution containing the red yeast rice extract, so that the weight ratio of monacolin K to phytosterols is 1:200. The ethanol-dried mixture of red yeast rice extract and phytosterol is crushed into powder.

[0047] Prepare 1000 capsules of the mixture of red yeast rice extract and phytosterol (assuming that the weight percentage of monacolin K in the red yeast rice extract is 5%).

[0048] The red yeast rice extract and phytosterol mixture material amount of above preparation are:

[0049] 500 grams x (1+0.005 / monacolin K...

example 2

[0053] Example 2: Red Yeast Extract Mixed with Phytosterol Esters

[0054] The dried red yeast rice powder was extracted with 75% ethanol, and the amount of monacolin K was determined by high performance phase chromatography (HPLC). The extract was evaporated to dryness, weighed and calculated the weight percentage of monacolin K in the extract (assuming that the weight percentage of monacolin K in the red yeast rice extract was 5%).

[0055] The amount of phytosterol in the phytosterol ester was determined (assuming that the phytosterol content was 50%).

[0056] Preparation of 1000 capsules mixed with red yeast rice extract and phytosterol ester

[0057] The red yeast extract dry material amount of above preparation is:

[0058] 2.5g / monacolin K weight percent in red yeast extract=2.5g / 0.05=50g

[0059] The amount of phytosterol esters is: 500 / 50% = 1000 ml

[0060] The amount of diluent is:

[0061] 100g-red yeast extract dry material amount=100g-50g=50g

[0062] 1000...

example 3

[0065] Example 3: Mixing Red Yeast Extract with Phytosterols / Edible Emulsifiers

[0066] Calcium stearoyl lactylate (or other edible emulsifiers such as sucrose fatty acid esters) is mixed in a heatproof container. The weight ratio is from 20:1 to 1:5. Heat to about 140 degrees Celsius. At this moment, both the phytosterol and the calcium stearoyl lactylate were in a liquid state. Mix the two and cool to room temperature to form a solid. Then crush it into powder with a pulverizer, and pass through a 100-mesh sieve.

[0067] Preparation of 1000 capsules mixed with red yeast rice extract and phytosterol ester

[0068] The red yeast extract dry material amount prepared in example 2 is:

[0069] 2.5 g / Monacolin K weight percentage=2.5 g / 0.05=50 g in the red yeast rice extract.

[0070] Phytosterol and calcium stearoyl lactylate powder mixture (weight ratio 4:1).

[0071] 500 grams+500 grams / weight ratio=500 grams+500 grams / 4=625 grams. The amount of diluent is:

[0072] ...

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Abstract

The present invention is new recipe and preparation process of blood fat reducing medicine. The recipe of blood fat reducing medicine consists of red yeast preparation and phytosterol, or red yeast preparation and phytosterol ester, or red yeast preparation, phytosterol and other compound, or red yeast preparation, phytosterol and other mixture. The present invention can reduce the synthesis of cholesterol in liver and inhibit the absorption of cholesterol in intestinal tract, has high curative effect and is safe to human body.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a new prescription for lowering blood fat and a preparation method thereof. Background technique: [0002] Cardiovascular and cerebrovascular diseases, including coronary heart disease, myocardial infarction, cerebral haemorrhage, hypertension, etc., are common diseases among people in our country and many other countries, and are the number one cause of death of the urban population in our country. A large number of long-term clinical and laboratory studies have proved that high levels of serum cholesterol, especially high levels of low-density lipoprotein cholesterol, are independent risk factors for the development of coronary heart disease, myocardial infarction, cerebral emaciation and other cardiovascular and cerebrovascular diseases. Lowering serum cholesterol levels is recognized as an important measure to reduce and delay the occurrence and development of cardiovascular a...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61P3/06A61P9/10
Inventor 李安国贺石林邓常青梁可仙李平
Owner 李安国
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