New recipe and prepn process of blood fat reducing medicine

A preparation and blood lipid technology, which is applied in the field of new formulations and preparations for reducing blood lipids, can solve the problems of decelerating cholesterol synthesis, single function, and poor effect on cholesterol levels, and achieve the effect of eliminating compensatory absorption increase

Inactive Publication Date: 2005-09-28
李安国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: because red yeast rice or red yeast rice preparations contain lovastatin, they have toxic and side effects on human kidneys, liver and muscles, and can only slow down the synthesis of cholesterol in the liver and canno

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example

[0045] Example 1: Red yeast extract and plant sterol co-dissolved and mixed:

[0046] The dry red yeast rice powder was not extracted with 75-100% ethanol, the extract was volatile, dried, weighed, and then dissolved in an appropriate amount of absolute ethanol. The amount of monacolin K was determined by high performance liquid chromatography (HPLC), and The weight percentage of monacolin K in the extract was calculated. In addition, plant sterols are added to the absolute ethanol solution containing the red yeast rice extract so that the weight ratio of monacolin K to plant sterols is 1:200. The co-dissolved mixture of red yeast rice extract and phytosterols is removed from ethanol, dried, and crushed into powder.

[0047] Prepare 1000 capsules of the mixture of red yeast rice extract and phytosterol (assuming that the weight percentage of monacolin K in the red yeast rice extract is 5%).

[0048] The amount of the red yeast rice extract and phytosterol mixture prepared above is...

Example

[0053] Example 2: Red yeast extract mixed with phytosterol ester

[0054] The dry powder of red yeast rice was extracted with 75% ethanol, and the amount of monacolin K was determined by high performance phase chromatography (HPLC). The extract was evaporated to dryness, weighed, and the weight percentage of monacolin K in the extract was calculated (assuming that the weight percentage of monacolin K in the red yeast rice extract is 5%).

[0055] The amount of phytosterol in the phytosterol ester is determined (assuming the phytosterol content is 50%).

[0056] Prepare 1000 red yeast rice extract and plant sterol ester mixed capsules

[0057] The amount of dried red yeast rice extract prepared above is:

[0058] 2.5g / weight percentage of monacolin K in red yeast rice extract=2.5g / 0.05=50g

[0059] The amount of phytosterol ester is: 500 / 50% = 1000 ml

[0060] The amount of diluent is:

[0061] 100g-red yeast extract dry material amount=100g-50g=50g

[0062] Mix 1000 ml of phytoste...

Example

[0065] Example 3: Red yeast extract mixed with phytosterol / edible emulsifier

[0066] Calcium stearoyl lactate (or other edible emulsifiers such as sucrose fatty acid esters) are mixed in a heat-resistant container. The weight ratio is 20:1 to 1:5. Heat to about 140 degrees Celsius. At this time, both phytosterol and calcium stearoyl lactate are in liquid form. Mix the two well and cool to room temperature to form a solid. Then use a pulverizer to break it into powder, and pass through a 100-mesh sieve.

[0067] Prepare 1000 red yeast rice extract and plant sterol ester mixed capsules

[0068] The amount of dried red yeast rice extract prepared in Example 2 is:

[0069] 2.5 g / weight percentage of monacolin K in red yeast rice extract=2.5 g / 0.05=50 g.

[0070] Phytosterol and calcium stearoyl lactate powder mixture (weight ratio 4:1).

[0071] 500g+500g / weight ratio=500g+500g / 4=625g. The amount of diluent is:

[0072] 175g-Red yeast extract dry material quantity=175g-50g=125g. The ...

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PUM

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Abstract

The present invention is new recipe and preparation process of blood fat reducing medicine. The recipe of blood fat reducing medicine consists of red yeast preparation and phytosterol, or red yeast preparation and phytosterol ester, or red yeast preparation, phytosterol and other compound, or red yeast preparation, phytosterol and other mixture. The present invention can reduce the synthesis of cholesterol in liver and inhibit the absorption of cholesterol in intestinal tract, has high curative effect and is safe to human body.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a new prescription for lowering blood fat and a preparation method thereof. Background technique: [0002] Cardiovascular and cerebrovascular diseases, including coronary heart disease, myocardial infarction, cerebral haemorrhage, hypertension, etc., are common diseases among people in our country and many other countries, and are the number one cause of death of the urban population in our country. A large number of long-term clinical and laboratory studies have proved that high levels of serum cholesterol, especially high levels of low-density lipoprotein cholesterol, are independent risk factors for the development of coronary heart disease, myocardial infarction, cerebral emaciation and other cardiovascular and cerebrovascular diseases. Lowering serum cholesterol levels is recognized as an important measure to reduce and delay the occurrence and development of cardiovascular a...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61P3/06A61P9/10
Inventor 李安国贺石林邓常青梁可仙李平
Owner 李安国
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