Use of saccharomyces cerevisiae ERG4 mutants for expressing mammalian glucose transporters

A technology for glucose transport and Saccharomyces cerevisiae, applied in the field of yeast strains, can solve the problems of low transporter activity, inactive transporter, retention, etc.
CN1694960AInactive Publication Date: 2005-11-09SANOFI AVENTIS DEUT GMBH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SANOFI AVENTIS DEUT GMBH
Publication Date
2005-11-09
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention relates to yeast strains in which a human GLUT4 transporter or a human GLUT1 transporter can be functionally expressed and in particular GLUT4 transport proteins which can be particularly easily functionally expressed in yeast strains.
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Description

field of invention

[0001] The present invention relates to yeast strains capable of functionally expressing human GLut4 and GLut1 transporters. Background technique

[0002] Most heterotrophic cells transport glucose into the cell via specific transport proteins. Different organisms have developed different mechanisms for mediating glucose transport, such as especially the proton co-transport system, Na + Glucose transporters, binding protein-dependent systems, phosphotransferase systems, and systems for facilitated diffusion. In eukaryotes, the family of glucose transporters encoded by the GLUT gene (GLUT = glucose transporter) in mammals and by the HXT gene (HXT = hexose transporter) in Saccharomyces cerevisiae Diffused glucose uptake. The transporters belong to the larger family of sugar transporters. They are characterized by the presence of 12 transmembrane helices and multiple conserved amino acid residues. Glucose transport plays an important role in disorders as...

Claims

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