Pseudoginsenoside Pdq and its semi-synthesis process and medicine use

A ginsenoside, semi-synthetic technology, applied in the direction of steroids, organic chemistry, etc., to achieve significant curative effect
CN1706862AActive Publication Date: 2005-12-14李平亚
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
李平亚
Publication Date
2005-12-14

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Abstract

The present invention relates to pseudoginseenoside-Pdq and its semi-synthesis process and medicinal use, and belongs to the field of new compound and its synthesis and medicinal use. The material 20(S)-protopanoxadiol saponin or 20(R)-protopanoxadiol saponin is processed through oxidation, cyclization and other steps under acid condition to produce pseudoginseenoside-Pdq as one new compound, named chemically as damar-20S, 20R-epoxy-3beta, 12beta, 25-triol. Pseudoginseenoside-Pdq has wide application in preparing medicine for treating coronary heart disease, myocardial ischemia, ischemic shock, arrhythmia, etc.
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Description

Technical field

[0001] The invention relates to pseudo-ginsenoside-Pdq and a semi-synthetic method thereof, and its application in preparing medicines for treating myocardial ischemia, ischemic shock, arrhythmia and reperfusion injury. Background technique

[0002] Since ginsenosides were confirmed as the main active ingredients in ginseng and American ginseng, chemists have devoted themselves to the synthesis of certain monomeric saponins and the conversion of effective monomers. At present, there are mainly the following methods in research and application, such as acid hydrolysis, alkaline hydrolysis, enzymatic hydrolysis, condensation, etc. The first three methods are mainly between total glycosides and monomer saponins, by hydrolyzing a certain part or several parts of the molecule to realize the conversion of a certain monomer saponins or children's monomer saponins; the latter is through sugar and The aglycon can obtain a certain monomer compound through the glycoside reac...

Claims

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