Stable recombination human interferon alpha 1b water solution

A technology of recombinant human interferon and interferon α, applied in the direction of interferon, cytokines/lymphokines/interferons, specific peptides, etc., can solve problems such as instability and long-term storage

Active Publication Date: 2006-01-25
BEIJING TRI PRIME GENE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when interferon exists in the state of aqueous solution, its main disadvantage is that it is unstable and cannot be stored for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare recombinant human interferon α1b aqueous solution according to the formula in Table 1, and dispense the solution prepared according to formula A into eye drop bottles to make eye drops; dispense the solutions prepared according to formula B and C into glass molds In the antibiotic bottle, it is made into injection; the solution prepared according to formula D is divided into aerosol bottles, and it is made into spray.

[0021] ingredients

Formula A

Formula B

Formula C

Formula D

interferon alpha 1b

NaCl

citrate

Disodium hydrogen phosphate dodecahydrate

human serum albumin

Tween 80

Add water for injection to

10mg

2.5g

0.6g

6.0g

5g

-

1000ml

30mg

7.0g

0.3g

3.0g

10g

-

1000ml

30mg

7.0g

0.3g

3.0g

l0g

1ml

1000ml

50mg

27g

0.15g

1.5g

20g

-

1000ml

[0022] ...

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PUM

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Abstract

The invention relates to a stabilized recombinant human interferon alpha1b water solution, where the water solution with a total volume of 1000ml contains, therapeutic effective dose of interferon alpha1b, 2.5-27.0g of sodium chloride, 0.15-0.60g of citric acid, 1.5-6.0g of dodecahydro-disodium phosphate, and 5-20g of human blood albumin.

Description

technical field [0001] The present invention relates to a stable aqueous solution of interferon. Background technique [0002] It has been more than 40 years since interferon was discovered in 1957. So far, great progress has been made in the research on the basic theory, production and preparation technology and clinical application of interferon. [0003] Recombinant human interferon α1b is suitable for chronic hepatitis B, hepatitis C, hairy cell leukemia, chronic myelogenous leukemia, condyloma acuminatum, and various infectious diseases and tumors, with a wide range of clinical applications and a large dosage. But this medicine mainly exists in the form of freeze-dried powder injection, needs to add water for injection during use, brings some inconvenience to clinical use, what is more important is that the manufacturing cost of powder injection is higher, and the price is expensive, so many people who need to use interferon It is unaffordable for patients, which seve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/56
Inventor 杨大军刘金毅刘永全孙俭波程永庆
Owner BEIJING TRI PRIME GENE PHARMA CO LTD
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