Nanometer grade liposome aluminium lactates addictive for daily used chemical product

The technology of nano-liposome and aluminum lactate is applied in the directions of cosmetics, cosmetics, cosmetic preparations, etc., and achieves the effects of simple preparation process, good anti-dentin hypersensitivity and good biocompatibility

Inactive Publication Date: 2006-02-22
CHONGQING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, for a specific daily chemical additive aluminum lactate, in order to obtain a nano-level liposomal aluminum lactate additive with excellent performance, how to choose a suitable main material for nano-sized liposomes, what process steps and process conditions are required, These are all that the prior art cannot directly teach and obtain, and there are still many technical problems

Method used

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  • Nanometer grade liposome aluminium lactates addictive for daily used chemical product
  • Nanometer grade liposome aluminium lactates addictive for daily used chemical product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Accurately weigh 50 mg of lecithin, 50 mg of cholesterol, and 25 mg of vitamin E into a 50 mL round bottom flask, add 20 mL of a mixed solvent of anhydrous methanol and chloroform with a volume ratio of 1, and shake to dissolve. Under the condition of 30°C, the mixed solvent was evaporated under reduced pressure on a rotary evaporator at a rate of 75r / min to form a uniform film on the inner wall of the round bottom flask. Add 18 mL of 20 mg Pluronic F dissolved in the flask with an uninterrupted tiny liquid column (0.2mm diameter) 68 (Pluronic F 68 ) And an aqueous solution of 40mg aluminum lactate, magnetically stirred for 4h under the condition of 1000r / min. Then, sonicate for 10 minutes in an ultrasonic generator at room temperature to obtain a nano-liposome mixture encapsulating aluminum lactate. Place this mixture in a dialysis bag with a cut-off molecular weight of 8000~12000, and dialyze it in a PBS buffer solution (pH=7.4) at 4°C for 24 hours to remove the unencapsu...

Embodiment 2

[0028] Accurately weigh 100mg of lecithin, 80mg of cholesterol, and 40mg of vitamin E into a 50mL round bottom flask, add 20mL of a mixed solvent of anhydrous methanol and chloroform with a volume ratio of 0.5, and shake to dissolve. Under the condition of 40°C, the mixed solvent was evaporated under reduced pressure on a rotary evaporator at a rate of 65r / min to form a uniform film on the inner wall of the round bottom flask. Add 20 mL of an aqueous solution containing 80 mg of Tween-60 and 40 mg of aluminum lactate to the flask in an uninterrupted tiny liquid column (diameter 0.3 mm), and magnetically stir for 6 hours under the condition of 1200 r / min. Then, sonicate for 10 minutes in an ultrasonic generator at room temperature to obtain a nano-liposome mixture encapsulating aluminum lactate. Place this mixture in a dialysis bag with a cut-off molecular weight of 8000~12000, and dialyze it in a PBS buffer solution (pH=7.4) at 4°C for 24 hours to remove the unencapsulated aluminu...

Embodiment 3

[0030]Accurately weigh 100mg of lecithin, 50mg of cholesterol, and 10mg of vitamin E into a 50mL round-bottomed flask, add 10mL of a mixed solvent of anhydrous methanol and chloroform with a volume ratio of 1.5, and shake to dissolve. Under the condition of 60°C, the mixed solvent was evaporated under reduced pressure on a rotary evaporator at a rate of 85r / min to form a uniform film on the inner wall of the round bottom flask. Add 15 mL of an aqueous solution containing 40 mg of polysorbate-80 and 40 mg of aluminum lactate to the flask in an uninterrupted tiny liquid column (diameter of 0.4 mm), and magnetically stir for 5 hours at 500 r / min. Then, sonicated in an ultrasonic generator at room temperature for 20 minutes to obtain a mixture of nano-liposomes encapsulating aluminum lactate. Place this mixture in a dialysis bag with a cut-off molecular weight of 8000~12000, and dialyze it in a PBS buffer solution (pH=7.4) at 0°C for 48 hours to remove the unencapsulated aluminum lact...

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Abstract

The invention discloses a nano grade liposome aluminum lactate additive used for toothpaste, deodorant, emulsion, face cream, lipstick, hair jelly, shampoo and liquid cleaner. The core of the additive is aluminum lactate, and the main ingredients of the liposome include lecithin, cholesterin and vitamin E.

Description

Technical field [0001] The invention belongs to the technical field of additives in fine chemicals, and relates to an aluminum lactate additive, in particular to a nano-level liposome aluminum lactate additive for daily chemical products. Background technique [0002] Aluminum Lactate, molecular formula Al[CH 3 CH(OH)COO] 3 , Molecular weight 294.20, white or yellow powdery solid, easily soluble in water. [0003] In recent years, the United States, Japan, the United Kingdom, Germany and other countries have conducted a large number of studies on the application and development and biological characteristics of aluminum lactate. Tests have shown that aluminum lactate is a new additive reagent for daily chemical products with definite efficacy (aluminum lactate is used in daily chemical Application in China / Xu Hong, Gou Jin, Chen Xin, etc. [J], "Daily Chemical Industry", 2001, 5: 64-65, 68). For example, aluminum lactate is used in toothpaste, which can pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61Q15/00A61Q19/00A61Q5/04A61Q1/04C11D3/00C11D3/48
Inventor 徐红陈新杨勇梁国明苟劲孙宇阳谌虹彭大权李荣
Owner CHONGQING NORMAL UNIVERSITY
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