Nanometer grade liposome aluminium lactates addictive for daily used chemical product

A nano-liposome and aluminum lactate technology, applied in cosmetics, cosmetics, skin care preparations, etc., to achieve high penetration, high activity, and good anti-dentin hypersensitivity effects

Inactive Publication Date: 2007-03-21
CHONGQING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, for a specific daily chemical additive aluminum lactate, in order to obtain a nanoscale liposomal aluminum lactate additive with excellent performance, how to choose a suitable main material for nanoscale liposomes, what process steps and process conditions are required, these All existing technologies cannot be directly taught to obtain, and there are still many technical problems

Method used

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  • Nanometer grade liposome aluminium lactates addictive for daily used chemical product
  • Nanometer grade liposome aluminium lactates addictive for daily used chemical product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Accurately weigh 50mg of lecithin, 50mg of cholesterol, and 25mg of vitamin E into a 50mL round bottom flask, add 20mL of a mixed solvent of anhydrous methanol and chloroform with a volume ratio of 1, and shake to dissolve. At 30°C, the mixed solvent was evaporated on a rotary evaporator at a rate of 75 r / min under reduced pressure until a uniform film was formed on the inner wall of the round bottom flask. Add 18mL dissolved in 20mg Pluronic F 68 (Pluronic F 68 ) and 40mg of aluminum lactate aqueous solution, under the condition of 1000r / min, magnetically stirred for 4h. Then, at room temperature, sonicate in an ultrasonic generator for 10 minutes to obtain a mixed solution of nanoliposomes wrapped with aluminum lactate. Place the mixed solution in a dialysis bag with a cut-off molecular weight of 8,000-12,000, and dialyze in PBS buffer solution (pH=7.4) at 4°C for 24 hours to remove unencapsulated aluminum lactate to obtain aluminum lactate-encapsulated nanolipid p...

Embodiment 2

[0028] Accurately weigh 100mg of lecithin, 80mg of cholesterol, and 40mg of vitamin E into a 50mL round bottom flask, add 20mL of anhydrous methanol and chloroform with a volume ratio of 0.5, and shake to dissolve. At 40°C, the mixed solvent was evaporated on a rotary evaporator at a rate of 65 r / min under reduced pressure until a uniform film was formed on the inner wall of the round bottom flask. Add 20 mL of an aqueous solution dissolved with 80 mg of Tween-60 and 40 mg of aluminum lactate into the flask in an uninterrupted micro liquid column (0.3 mm in diameter), and stir magnetically for 6 h at 1200 r / min. Then, at room temperature, sonicate in an ultrasonic generator for 10 minutes to obtain a mixed solution of nanoliposomes wrapped with aluminum lactate. Place the mixed solution in a dialysis bag with a cut-off molecular weight of 8,000-12,000, and dialyze in PBS buffer solution (pH=7.4) at 4°C for 24 hours to remove unencapsulated aluminum lactate to obtain aluminum l...

Embodiment 3

[0030]Accurately weigh 100 mg of lecithin, 50 mg of cholesterol, and 10 mg of vitamin E into a 50 mL round bottom flask, add 10 mL of a mixed solvent of anhydrous methanol and chloroform with a volume ratio of 1.5, and shake to dissolve. At 60°C, the mixed solvent was evaporated on a rotary evaporator at a rate of 85 r / min under reduced pressure until a uniform film was formed on the inner wall of the round bottom flask. Add 15 mL of an aqueous solution containing 40 mg of polysorbate-80 and 40 mg of aluminum lactate into the flask in an uninterrupted micro liquid column (0.4 mm in diameter), and stir magnetically for 5 h at 500 r / min. Then, at room temperature, sonicate in an ultrasonic generator for 20 minutes to obtain a mixed solution of nanoliposomes wrapped with aluminum lactate. Place the mixed solution in a dialysis bag with a cut-off molecular weight of 8,000-12,000, and dialyze in a PBS buffer solution (pH=7.4) at 0°C for 48 hours to remove unencapsulated aluminum la...

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Abstract

The invention discloses a nano grade liposome aluminum lactate additive used for toothpaste, deodorant, emulsion, face cream, lipstick, hair jelly, shampoo and liquid cleaner. The core of the additive is aluminum lactate, and the main ingredients of the liposome include lecithin, cholesterin and vitamin E.

Description

technical field [0001] The invention belongs to the technical field of additives in fine chemicals, and relates to an aluminum lactate additive, in particular to a nano-scale liposomal aluminum lactate additive for daily chemical products. Background technique [0002] Aluminum Lactate (Aluminum Lactate), molecular formula Al[CH 3 CH(OH)COO] 3 , molecular weight 294.20, white or yellow powdery solid, soluble in water. [0003] In recent years, the United States, Japan, the United Kingdom, Germany and other countries have conducted a lot of research on the application and development of aluminum lactate and its biological characteristics. Tests have shown that aluminum lactate is a new type of additive reagent for daily chemical products with definite efficacy (aluminum lactate is used in daily chemical products Application in Chinese medicine / Xu Hong, Gou Jin, Chen Xin, etc. [J], "Daily Chemical Industry", 2001, 5: 64-65, 68). For example, aluminum ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/365A61Q15/00A61Q19/00A61Q5/04A61Q1/04C11D3/00C11D3/48
Inventor 徐红陈新杨勇梁国明苟劲孙宇阳谌虹彭大权李荣
Owner CHONGQING NORMAL UNIVERSITY
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