Synthesis process of carbamido carboxymethyl chitosan

Abstract

The synthesis process of casbamido carboxymethyl chitosan is reaction of carboxymethyl chitosan and isocyanate inside proper solvent of N, N-dimehyl formamide and anhydrous acetic acid. Research shows that the obtained casbamido carboxymethyl chitosan derivative has chitosan amino group substituting degree as high as 20.3-46.5 %, high water solubility, strengthened bioactivity, synergistic effect and enlarged application range in medicine, agriculture and other fields.

Description

technical field [0001] The invention belongs to the technical field of marine chemical engineering and relates to a new synthesis technology of ureido carboxymethyl chitosan derivatives. Background technique [0002] The development of pesticides is a high-tech, high-investment, and high-risk project. At present, it takes about 5-8 years to develop a new variety, costing 100-200 million U.S. dollars, and screening about 100,000 compounds. Environmental concerns demand that these numbers increase. At present, only major international pesticide companies such as Aventis, Bayer, and Monsanto have the ability to independently develop new varieties. How to research and develop new pesticides in our country is a serious problem faced with the entry into WTO and the protection of intellectual property rights is becoming more and more perfect. [0003] According to the actual situation and research direction of the international fungicide market, the activity and occurrence of var...

AI Technical Summary

Problems solved by technology

Urea compounds are widely used in the existing pesticide fungicides, and have good bactericidal effect. There is a free amino group at the C2 position of chitosan, which can react with isocyanate and connect groups with different activities to obtain active High chitosan derivatives, but such chitosan derivatives have poor water solubility and limited application range

[0005] Carboxymethyl chitosan has good water solubility and good antibacterial activity, but there are few products that further modify carboxymethyl chitosan. The substituents of carboxymethyl chitosan are connected to chitosan Hydroxyl and amino groups, but the degree of substitution of amino groups is only 0.1-0.2, (Chen Lingyun, Du Yumin, Liu Yi, Research on the structure and antibacterial properties of carboxymethyl chitosan, Journal of Wuhan University (Natural Science Edition), 2000, 45, 191-194), for chitosan whose degree of deacetylation reaches 97%, about 80% of amino groups can participate in the reaction, so further modification of chitosan has great development prospects

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