Medicinal composition and its use in preparing medicine for treating or preventing cardio-cerebral vascular diseases
A composition and drug technology, applied in cardiovascular system diseases, drug combination, drug delivery, etc., can solve the problem of unreported synergy
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preparation example 1
[0020] Preparation example 1: preparation of magnolol and its magnesium salt, sodium salt; honokiol and its magnesium salt, sodium salt
[0021] According to the literature [Zhang Zhongyi, Huang Changquan, Lei Zhengjie, et al. Supercritical CO 2 Research on extracting magnolol. Guangdong Pharmacy, 1999, 9(3): 20.] Prepared by the method described.
[0022] After 12.5kg of magnolia bark is pulverized, put it into the extraction kettle, heat the extraction kettle, the analysis kettle I, and the analysis kettle II respectively, and when the temperature reaches 35°C, 40°C, and 37°C, the extraction kettle, the two The analysis kettle was pressurized, and when the pressure reached 22mPa, 7.5mPa and 6mPa respectively, the circular extraction was started, and the constant temperature and pressure were kept, and each cycle was 10min, and the materials were discharged from the analysis kettle I and III to obtain 605g of a light yellow extract. for 4h. Dissolve Magnolia officinalis ext...
preparation example 2
[0027] Preparation example 2: Preparation of a freeze-dried powder injection with magnolol magnesium salt and honokiol magnesium salt as active ingredients
[0028] Under clean conditions, take 30g of magnolol magnesium salt and 60g of honokiol magnesium salt, dissolve them in 1000ml of water for injection, add 100g of mannitol, stir to dissolve, and ultrafilter to obtain a pyrogen-free clear solution, press lyophilized powder for injection The process is freeze-dried to make a freeze-dried powder injection containing 30 mg of magnesium salt of magnolol and 60 mg of magnesium salt of honokiol.
[0029] Under clean conditions, take 18g of magnolol magnesium salt and 72g of honokiol magnesium salt, dissolve them in 1000ml of water for injection, add 100g of mannitol, stir to dissolve, and ultrafilter to obtain a pyrogen-free clear solution, press the freeze-dried powder injection The process is freeze-dried to make a freeze-dried powder injection containing 18 mg of magnolol mag...
preparation example 3
[0030] Preparation Example 3: Preparation of a freeze-dried powder injection with magnolol sodium salt and honokiol sodium salt as active ingredients
[0031] Under clean conditions, take 60g of magnolol sodium salt and 30g of honokiol sodium salt, add polyoxyethylene glycerol triricinoleate-3L (EL-35) 180ml, dissolve in 1000ml of water for injection, add and stir to dissolve, Ultrafiltration was obtained to obtain a pyrogen-free clear liquid, which was freeze-dried according to the freeze-dried powder injection process to make a freeze-dried powder injection containing 60 mg of magnolol sodium salt and 30 mg of honokiol sodium salt.
[0032]Under clean conditions, take 72g of magnolol sodium salt and 18g of honokiol sodium salt, add polyoxyethylene glycerol triricinoleate-3L (EL-35) 180ml, dissolve in 1000ml of water for injection, add and stir to dissolve, Ultrafiltration was obtained to obtain a pyrogen-free clear solution, which was freeze-dried according to the freeze-dri...
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