Aibomycin analogue, its preparation method, medicinal composition and use

A composition and drug technology, applied in the field of epothilone analogues, can solve problems such as weakening natural products
CN1752078AInactive Publication Date: 2006-03-29BETA PHARMA (SHANGHAI) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BETA PHARMA (SHANGHAI) CO LTD
Publication Date
2006-03-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

An Aibomycine analog, its preparing process, its composite medicines, and its application for treating cancers and hyperplastic diseases and inducing apoptosis are disclosed.
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Description

field of invention

[0001] The present invention relates to a macrocyclic compound with antitumor activity, a preparation method of the compound, a pharmaceutical composition containing the compound and a use method of the compound. More specifically, the present invention relates to a series of stable metabolized epothilone analogs as antineoplastic agents. Background of the invention

[0002] Macrolide compounds useful in the pharmaceutical field of epothilones. For example, epothilones A and B were found to have the structure

[0003]

[0004] R in epothilone A stands for H, and R in epothilone B stands for Me

[0005] Plays a microtubule stabilizing effect similar to paclitaxel, and thus has cytotoxic activity against rapidly proliferating cells (such as tumor cells or other hyperproliferative cell diseases). Hofle, G. et al [Angew.Chem.Int.Ed.Engl., Vol. 35, No.13 / 14, 1567-1569 (1996); WO93 / 10121 published on May 27, 1993 and May ...

Claims

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